Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. Journal Of Neuroscience 2011, 31: 1863-1872. PMID: 21289196, PMCID: PMC3037097, DOI: 10.1523/jneurosci.4230-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdult ChildrenAnimalsAntipsychotic AgentsCerebral CortexDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Early Growth Response Protein 2FemaleFrontal LobeGlutamic AcidHallucinogensInfluenza A Virus, H1N1 SubtypeMaternal-Fetal ExchangeMiceNeural PathwaysOrthomyxoviridae InfectionsPregnancyProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaUp-RegulationConceptsInfluenza viral infectionViral infectionMouse modelAdult offspringSchizophrenia-like alterationsPrenatal viral infectionHead-twitch responseSchizophrenia-like psychosisInfluenza A/WSN/33 virusMetabotropic glutamate receptorsAntipsychotic-like effectsPrevention of schizophreniaSpontaneous locomotor activityHigher c-fosEffects of hallucinogensBehavioral changesEgr-2 expressionEtiology of schizophreniaMechanism of actionMaternal infectionInfected mothersMaternal exposureGlutamate agonistsAntipsychotic drugsGlutamate system