Featured Publications
Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
Ching T, Grazioplene R, Bohner C, Kichuk S, DePalmer G, D’Amico E, Eilbott J, Jankovsky A, Burke M, Hokanson J, Martins B, Witherow C, Patel P, Amoroso L, Schaer H, Pittenger C, Kelmendi B. Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial. Frontiers In Psychiatry 2023, 14: 1178529. PMID: 37181888, PMCID: PMC10166878, DOI: 10.3389/fpsyt.2023.1178529.Peer-Reviewed Original ResearchObsessive-compulsive disorderPrimary endpointPsilocybin effectsNeural effectsRefractory obsessive-compulsive disorderNon-crossover designOpen-label doseStandard care treatmentOpen-label studyVisual analog scale ratingsTreatment of OCDEffects of psilocybinOCD symptomsInstitutional review boardYale-Brown ObsessivePrimary outcomeSingle doseCare treatmentOral psilocybinInformed consentReview boardNeurobiological mechanismsCompulsive ScalePsychological supportTrials
2022
Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report
Kelmendi B, Kichuk S, DePalmer G, Maloney G, Ching T, Belser A, Pittenger C. Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report. Heliyon 2022, 8: e12135. PMID: 36536916, PMCID: PMC9758406, DOI: 10.1016/j.heliyon.2022.e12135.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment of OCDPsychedelic treatmentTreatment-resistant obsessive-compulsive disorderRefractory obsessive-compulsive disorderOCD symptomsPsychological effectsSerotonin systemSingle experimental studyRecreational usersBrain serotonin systemTreatment of patientsClassic psychedelicsQuality of lifePsilocybinSymptomatic improvementCase reportClinical dataTherapeutic potentialEmotionsPatientsDisordersTreatmentNumber of conditionsCompulsion
2020
Association Splitting for Obsessive-Compulsive Disorder: A Systematic Review
Ching T, Jelinek L, Hauschildt M, Williams M. Association Splitting for Obsessive-Compulsive Disorder: A Systematic Review. Current Psychiatry Research And Reviews 2020, 15: 248-260. DOI: 10.2174/2352096512666190912143311.Peer-Reviewed Original ResearchCognitive behavior therapyObsessive-compulsive disorderAssociation splittingSelf-help interventionOCD symptomsFace cognitive behavior therapyStandard cognitive behavior therapySpecific OCD symptomsOCD symptom severityDifferent symptom dimensionsLarge effect sizesLanguage of administrationCognitive techniquesEase of comprehensionSemantic associationsSymptom dimensionsUnwanted intrusionsMajority of participantsSymptom severityComparison groupEffect sizeAppropriate comparison groupsSample characteristicsFuture studiesHigh acceptability
2017
Association splitting of the sexual orientation-OCD-relevant semantic network
Ching THW, Williams MT. Association splitting of the sexual orientation-OCD-relevant semantic network. Cognitive Behaviour Therapy 2017, 47: 229-245. PMID: 28681684, DOI: 10.1080/16506073.2017.1343380.Peer-Reviewed Original ResearchConceptsAssociation splittingSO-OCDOCD symptomsEmotional valenceSexual obsessionsOverall large effect sizeNew cognitive approachWaitlist control groupSemantic networkSelf-help techniquesLarge effect sizesCognitive mechanismsCue wordsAssociation taskCognitive approachCognitive techniquesCompulsive disorderHeterosexual undergraduatesNeutral associationsAS groupEffect sizeFuture researchLittle researchObsessionValence