2023
Left Ventricular Ejection Fraction and the Future of Heart Failure Phenotyping
Dimond M, Ibrahim N, Fiuzat M, McMurray J, Lindenfeld J, Ahmad T, Bozkurt B, Bristow M, Butler J, Carson P, Felker G, Jessup M, Murillo J, Kondo T, Solomon S, Abraham W, O'Connor C, Psotka M. Left Ventricular Ejection Fraction and the Future of Heart Failure Phenotyping. JACC Heart Failure 2023, 12: 451-460. PMID: 38099892, DOI: 10.1016/j.jchf.2023.11.005.Peer-Reviewed Original ResearchElectronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure
Fuery M, Kadhim B, Samsky M, Freeman J, Clark K, Desai N, Wilson F, Ahmed T, Ahmad T. Electronic Health Record Embedded Strategies for Improving Care of Patients With Heart Failure. Current Heart Failure Reports 2023, 20: 280-286. PMID: 37552356, DOI: 10.1007/s11897-023-00614-0.Peer-Reviewed Original ResearchConceptsHeart failure patientsFailure patientsElectronic health recordsEHR alertClinical trialsRandomized clinical trialsCare of patientsQuality of careHeart failureClinician satisfactionRandomized fashionRecent FindingsTherePatientsUnmet needPatient careClinical decisionEvidence-based decisionsFuture interventionsCareHealth recordsTrialsCliniciansInterventionFindingsThereUse of patient‐reported outcomes in heart failure: from clinical trials to routine practice
Savarese G, Lindenfeld J, Stolfo D, Adams K, Ahmad T, Desai N, Ammirati E, Gottlieb S, Psotka M, Rosano G, Allen L. Use of patient‐reported outcomes in heart failure: from clinical trials to routine practice. European Journal Of Heart Failure 2023, 25: 139-151. PMID: 36644876, DOI: 10.1002/ejhf.2778.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesHeart failureHF careApplication of PROsClinical practiceDisease statusMortality/morbidityPatient-centered approachQuality of lifeDaily clinical routinePerception of diseasePhysician assessmentClinical trialsTraditional careComplex syndromeOwn carePatient experiencePatient's lifeRoutine practiceSymptom severityClinical routineModalities of usePatient's standpointCareTrials
2022
Functional and Symptomatic Clinical Trial Endpoints The HFC-ARC Scientific Expert Panel
Psotka M, Abraham W, Fiuzat M, Filippatos G, Lindenfeld J, Ahmad T, Felker G, Jacob R, Kitzman D, Leifer E, Lewis E, Mentz R, Nkulikiyinka R, Ni W, Schaber D, Sharma A, Solomon S, Stockbridge N, Teerlink J, Unger E, Whellan D, Wittes J, Anker S, O'Connor C. Functional and Symptomatic Clinical Trial Endpoints The HFC-ARC Scientific Expert Panel. JACC Heart Failure 2022, 10: 889-901. PMID: 36456063, DOI: 10.1016/j.jchf.2022.09.012.Peer-Reviewed Original ResearchConceptsAcademic Research ConsortiumHeart failureSubmaximal exercise tolerancePatient-reported outcomesCardiovascular clinical researchResearch ConsortiumExercise toleranceScientific Expert PanelPatients' qualityFunctional statusClinical trialsLife endpointsConsensus recommendationsClinical utilityDrug AdministrationCardiovascular therapeuticsClinical researchU.S. FoodExpert panelPotential endpointsNational InstituteEvidence generationTrialsEndpointAcademic investigators
2021
Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials
Miller PE, Van Diepen S, Metkus TS, Alviar CL, Rayner-Hartley E, Rathwell S, Katz JN, Ezekowitz J, Desai NR, Ahmad T. Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials. Journal Of Cardiac Failure 2021, 27: 602-606. PMID: 33556546, PMCID: PMC8527461, DOI: 10.1016/j.cardfail.2021.01.018.Peer-Reviewed Original ResearchConceptsAcute heart failureBaseline ejection fractionMechanical ventilationRespiratory failureHeart failureClinical trialsClinical outcomesHF etiologyHF rehospitalizationEjection fractionAcute HF admissionBaseline diabetes mellitusHF clinical trialsMechanical ventilation groupMechanical ventilation useProportion of patientsChronic lung diseaseMultivariable logistic regressionOriginal clinical trialsCause mortalityHF admissionsIndex hospitalizationMultivariable adjustmentSmoking historyVentilation group
2020
Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure
Mezzacappa C, Ravindra NG, Caraballo C, Chouairi F, Miller PE, Clarke JD, Gruen J, Mori M, McCullough M, Mullan C, Geirsson A, Rogers JG, Anwer M, Desai N, Ahmad T. Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure. PLOS ONE 2020, 15: e0242928. PMID: 33270648, PMCID: PMC7714148, DOI: 10.1371/journal.pone.0242928.Peer-Reviewed Original ResearchConceptsClinical trialsVentricular assist deviceExclusion criteriaLVAD recipientsAssist deviceReal-world settingClinical implicationsClinical trial exclusion criteriaHeart failure clinical trialsEnd-stage renal diseaseEnd-stage heart failureReal-world registryRetrospective cohort studyLandmark clinical trialsStage renal diseaseTrial exclusion criteriaRisk of deathStage heart failureRespiratory failureCohort studyPatient characteristicsHeart failurePatient factorsRenal diseaseClinical outcomesConduct of Clinical Trials in the Era of COVID-19 JACC Scientific Expert Panel
Psotka MA, Abraham WT, Fiuzat M, Filippatos G, Lindenfeld J, Ahmad T, Bhatt AS, Carson PE, Cleland JGF, Felker GM, Januzzi JL, Kitzman DW, Leifer ES, Lewis EF, McMurray JJV, Mentz RJ, Solomon SD, Stockbridge N, Teerlink JR, Vaduganathan M, Vardeny O, Whellan DJ, Wittes J, Anker SD, O'Connor CM. Conduct of Clinical Trials in the Era of COVID-19 JACC Scientific Expert Panel. Journal Of The American College Of Cardiology 2020, 76: 2368-2378. PMID: 33183511, PMCID: PMC7836888, DOI: 10.1016/j.jacc.2020.09.544.Peer-Reviewed Original ResearchConceptsAcademic Research ConsortiumClinical trialsExpert consensus recommendationsResearch ConsortiumScientific Expert PanelHeart failureCardiovascular diseaseConsensus recommendationsClinical careDrug AdministrationCoronavirus diseaseU.S. FoodExpert panelNational InstituteTrialsCOVID-19 pandemicDiseaseAcademic investigatorsHeartKey recommendationsSeries of meetingsPandemicPatientsAdministrationCare
2015
Use of outcome measures in pulmonary hypertension clinical trials
Parikh KS, Rajagopal S, Arges K, Ahmad T, Sivak J, Kaul P, Shah SH, Tapson V, Velazquez EJ, Douglas PS, Samad Z. Use of outcome measures in pulmonary hypertension clinical trials. American Heart Journal 2015, 170: 419-429.e3. PMID: 26385024, DOI: 10.1016/j.ahj.2015.06.010.Peer-Reviewed Original ResearchConceptsHypertension clinical trialsPulmonary arterial hypertensionPAH trialsClinical practiceInvasive hemodynamicsPrimary endpointClinical trialsOutcome measuresInvasive measuresSurrogate measureDuke University Medical CenterPatient-centered endpointsSecondary outcome measuresClinical treatment trialsMEDLINE/EMBASEUniversity Medical CenterSmall patient populationQuality of lifeContemporary clinical practicePAH therapyPH medicationsArterial hypertensionSerial echocardiographyPatient characteristicsSecondary outcomes
2013
Therapeutic Implications of Biomarkers in Chronic Heart Failure
Ahmad T, O'Connor C. Therapeutic Implications of Biomarkers in Chronic Heart Failure. Clinical Pharmacology & Therapeutics 2013, 94: 468-479. PMID: 23856627, DOI: 10.1038/clpt.2013.139.Peer-Reviewed Original ResearchConceptsChronic heart failureHeart failureTherapeutic implicationsBiomarker-guided clinical trialsTreatment of HFPotential therapeutic implicationsClinical trial designImportant therapeutic implicationsUse of biomarkersHemodynamic disordersClinical trialsClinical careTrial designTherapeutic potentialBiomarker studiesMolecular biomarkersBiomarkersMolecular dysfunctionMolecular pathwaysDysfunctionFailurePathophysiologySyndromeTrialsCare