2013
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience 2013, 16: 1042-1048. PMID: 23817550, DOI: 10.1038/nn.3449.Peer-Reviewed Original ResearchMeSH KeywordsAdenineAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsCocaineCorpus StriatumDopamineDopaminergic NeuronsExploratory BehaviorFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsLocomotionMaleMesencephalonMethylationMethyltransferasesMiceMice, Inbred C57BLMice, KnockoutMixed Function OxygenasesOxo-Acid-LyasesPhenotypeQuinpiroleReceptors, Dopamine D2Receptors, Dopamine D3RewardRNA Processing, Post-TranscriptionalRNA, MessengerSignal Transduction
2008
Brain circuits regulating energy homeostasis
Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Peptides 2008, 149: 3-10. PMID: 18514925, PMCID: PMC2605273, DOI: 10.1016/j.regpep.2007.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainEnergy MetabolismGhrelinHomeostasisHumansHypothalamusInsulinLeptinMesencephalonModels, Biological
2006
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal Of Clinical Investigation 2006, 116: 3229-3239. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/jci29867.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAppetiteDopamineFluorescent Antibody TechniqueGhrelinMaleMesencephalonMiceMice, Inbred C57BLMice, KnockoutNeuronsNucleus AccumbensPatch-Clamp TechniquesPeptide HormonesRatsRats, Sprague-DawleyReceptors, GhrelinReceptors, G-Protein-CoupledTime FactorsVentral Tegmental AreaConceptsVentral tegmental areaGHSR-deficient miceGHSR-dependent mannerGut hormone ghrelinDopamine neuronal activityMidbrain dopamine neuronsMesolimbic reward circuitrySynaptic input organizationPeripheral ghrelinRebound feedingVTA administrationOrexigenic effectDopamine turnoverGHSR antagonistDopamine neuronsHypothalamic centersTegmental areaHormone ghrelinNucleus accumbensGhrelinNeuronal activitySynapse formationReward circuitryInput organizationFeeding schedule