2018
Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures
Kiss DS, Ioja E, Toth I, Barany Z, Jocsak G, Bartha T, Horvath TL, Zsarnovszky A. Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures. International Journal Of Molecular Sciences 2018, 19: 1440. PMID: 29751674, PMCID: PMC5983839, DOI: 10.3390/ijms19051440.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebellumEstrogens, Non-SteroidalGene Expression RegulationNeuronsPrimary Cell CultureRatsThyroid Hormone Receptors alphaThyroid Hormone Receptors betaZearalenoneConceptsQuantitative reverse transcription polymerase chain reactionThyroid hormonesExpression levelsAbsence of gliaExpression of TRsReverse transcription-polymerase chain reactionThyroid receptor alphaTranscription-polymerase chain reactionPrimary cerebellar neuronsPrimary cerebellar granule cellsPrimary cerebellar cell culturesPostnatal brain developmentCerebellar granule cellsSerious health problemCerebellar cell culturesHormonal milieuGlial cellsBeta expressionGranule cellsReceptor alphaReceptor αThyroid receptor αHealth problemsLow dosesCerebellar neurons
2016
Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine
Jocsak G, Kiss DS, Toth I, Goszleth G, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine. International Journal Of Environmental Research And Public Health 2016, 13: 619. PMID: 27338438, PMCID: PMC4924076, DOI: 10.3390/ijerph13060619.Peer-Reviewed Original ResearchConceptsERβ mRNA expressionModulatory roleMRNA expressionCerebellar cell culturesGlial cellsEstrogen receptor β mRNA expressionEndocrine disruptorsAbsence of E2ED effectsPrimary cerebellar cell culturesΒ mRNA expressionAdverse health effectsHormonal milieuBody of evidenceHormone deficiencyCell culturesTriiodo-ThyronineHealth effectsEnvironmental substancesSimultaneous exposureEstradiolComparison of individualsObserved potencyE2T3
2001
Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function
Lephart E, Lund T, Horvath T. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Research Reviews 2001, 37: 25-37. PMID: 11744072, DOI: 10.1016/s0165-0173(01)00111-4.Peer-Reviewed Original ResearchConceptsDimorphic brain structuresAnteroventral periventricular nucleusBrain structuresEffects of phytoestrogensLow phytoestrogen dietPeripheral tissue sitesBrain aromatase cytochrome P450Brain androgenPhytoestrogen dietFemale ratsPeriventricular nucleusPreoptic areaCalcium-binding proteinsAromatase cytochrome P450Dimorphic nucleusTissue sitesCalbindinSteroid productsPotential roleSpatial memoryVisual-spatial memoryP450aroCytochrome P450Recent reportsPhytoestrogens