2016
Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
Jiang M, Qiu Z, Zhang S, Fan X, Cai X, Xu B, Li X, Zhou J, Zhang X, Chu Y, Wang W, Liang J, Horvath T, Yang X, Wu K, Nie Y, Fan D. Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling. Oncotarget 2016, 7: 61390-61402. PMID: 27542217, PMCID: PMC5308659, DOI: 10.18632/oncotarget.11359.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosamineAnimalsCell CycleCell Line, TumorCell ProliferationCyclin D1Cyclin-Dependent Kinase 2Down-RegulationFemaleGene Knockdown TechniquesHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred BALB CMice, NudeMiddle AgedMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3N-AcetylglucosaminyltransferasesPhosphorylationProtein Processing, Post-TranslationalRNA InterferenceRNA, Small InterferingSerineStomach NeoplasmsThreonineUp-RegulationXenograft Model Antitumor AssaysConceptsO-GlcNAcylationERK 1/2GlcNAcylation levelsCell cycleInhibition of OGTCell proliferationVivo xenograft assaysGastric cancer cell proliferationGC cell proliferationERK 1/2 pathwayERK-1/2 signalingThreonine residuesGastric cancer cell linesGlcNAc transferaseO-GlcNAcCancer cell proliferationTarget proteinsOGT levelsGastric epithelial cellsOnly enzymeXenograft assayPotential novel therapeutic targetPhosphorylation levelsCDK-2Cancer cell lines
2002
ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury
Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli S, Tinnikov AA. ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury. Journal Of Neuroscience 2002, 22: 8391-8401. PMID: 12351713, PMCID: PMC6757764, DOI: 10.1523/jneurosci.22-19-08391.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBlotting, WesternBrain IschemiaCaveolaeCell MembraneCell-Free SystemCells, CulturedCholesterolEnzyme ActivationEstradiolGene Expression Regulation, DevelopmentalIonophoresMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNeocortexNeuronsReceptors, EstrogenRNA, MessengerSignal TransductionSubcellular FractionsSubstrate SpecificityConceptsMAPK cascadePlasma membraneExtracellular signal-regulated kinases ERK1Neuronal differentiationPlasma membrane-associatedPlasma membrane-associated ERsProtein kinase isoformsCell-free systemMembrane-associated ERER alphaPutative ERKinases ERK1Cell divisionER betaSustained phosphorylationKinase isoformsERK activationMembrane-associatedGene-disrupted miceNovel mechanismEstrogen receptorUterine plasma membranesInhibitory regulatorIschemic stroke injuryIschemic brain injury