2022
TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice
Stoiljkovic M, Gutierrez KO, Kelley C, Horvath TL, Hajós M. TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal Of Alzheimer's Disease 2022, 88: 837-847. PMID: 34120899, PMCID: PMC8898080, DOI: 10.3233/jad-210041.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseMicroglial functionTREM2 functionTheta-phase gamma-amplitude couplingHippocampal network functionSpontaneous epileptiform seizuresNetwork oscillationsTransgenic AD modelHippocampal neuronal excitabilityMyeloid cells 2Clinical Alzheimer's diseaseWild-type miceHippocampal network oscillationsHippocampal pathophysiologyProgressive dementiaTau pathologyUrethane anesthesiaAD pathophysiologyNeuronal excitabilityEpileptiform seizuresEpileptic activityAD modelTREM2Disease pathologyCells 2Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathology
Stoiljkovic M, Gutierrez K, Kelley C, Horvath T, Hajos M. Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid‐β pathology. Alzheimer's & Dementia 2022, 17 DOI: 10.1002/alz.054379.Peer-Reviewed Original ResearchAlzheimer's diseaseNeuronal network oscillationsMicroglial functionNetwork oscillationsStimulation-induced hippocampal theta oscillationTheta-phase gamma-amplitude couplingImpact of TREM2Spontaneous epileptiform seizuresTransgenic AD modelMyeloid cells 2Wild-type miceHippocampal network oscillationsHippocampal theta oscillationsProgressive dementiaTau pathologyUrethane anesthesiaLocal field potentialsCA1 regionFunctional impairmentAβ overproductionEpileptiform seizuresAD modelTREM2Phase-amplitude couplingDisease pathology
2018
Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology. Cerebral Cortex 2018, 29: 2716-2727. PMID: 29920597, PMCID: PMC7302691, DOI: 10.1093/cercor/bhy140.Peer-Reviewed Original ResearchConceptsTgF344-AD ratsHippocampal theta oscillationsAlzheimer's diseaseDisease pathologyTheta-phase gamma-amplitude couplingAge-matched wild-type counterpartsAD pathological featuresDisease-modifying therapiesAccumulation of amyloidPredictive animal modelsAlzheimer's disease pathologyHigh-voltage spindlesTheta oscillationsSignificant age-dependent declineAge-dependent declineHippocampal excitabilitySharp-wave ripplesAβ accumulationNeuronal lossAD ratsPathological featuresUrethane anesthesiaAD patientsAuditory gatingAD drugs