2006
Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake
Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake. Neuron 2006, 51: 239-249. PMID: 16846858, DOI: 10.1016/j.neuron.2006.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEatingElectric StimulationMaleMiceMice, Inbred AMice, Inbred C57BLMice, KnockoutMice, ObeseMice, TransgenicNerve NetNeuronsPyridinesReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Receptor, Serotonin, 5-HT1BReceptors, MelanocortinSerotoninSerotonin 5-HT1 Receptor AgonistsConceptsFood intakePeripheral adiposity signalsBody weight homeostasisCentral serotonergic systemMelanocortin receptor agonistModulates food intakeSerotonin1B receptorsMelanocortin neuronsWeight homeostasisMelanocortin-3Receptor agonistSerotonergic regulationAdiposity signalsSerotonergic systemEndogenous releaseMelanocortin-4Central circuitryBody weightNeural pathwaysMelanocortin receptorsReceptorsDownstream activationAgonistsAntagonistIntake
2005
Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons
Abizaid A, Mezei G, Thanarajasingam G, Horvath TL. Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons. European Journal Of Neuroscience 2005, 21: 1536-1546. PMID: 15845081, DOI: 10.1111/j.1460-9568.2005.03964.x.Peer-Reviewed Original ResearchConceptsOvariectomized ratsRaphe nucleusDorsal raphe serotonergic neuronsEstradiol-treated ovariectomized ratsAbility of estradiolDouble-labeled cellsFos-immunoreactive cellsRaphe serotonergic neuronsMedian raphe nucleusFos-positive nucleiRaphe nuclei regionMidbrain rapheSerotonin immunocytochemistryOvarian functionSerotonergic neuronsEstrogen treatmentFos immunoreactivitySerotonergic systemFood intakeNeuronal responsesDirect projectionsPhotic stimulationEstradiolEstrogenNormal onset
2002
Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe
Fernández‐Galaz M, Diano S, Horvath TL, Garcia‐Segura L. Leptin Uptake by Serotonergic Neurones of the Dorsal Raphe. Journal Of Neuroendocrinology 2002, 14: 429-434. PMID: 12047717, DOI: 10.1046/j.1365-2826.2002.00783.x.Peer-Reviewed Original ResearchConceptsEffects of leptinRaphe nucleusDorsal rapheFemale ratsMidbrain serotonergic systemsSerotonergic systemSerotonergic neuronesRaphe neuronesDistribution of neuronesMouse recombinant leptinIntracerebroventricular administrationLeptin administrationLeptin uptakeLeptin treatmentPeriventricular grayMale ratsFood intakeRecombinant leptinLeptinSleep patternsGender differencesBrain functionImportant mediatorLeptin accumulationNeurones