GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia
Li NX, Brown S, Kowalski T, Wu M, Yang L, Dai G, Petrov A, Ding Y, Dlugos T, Wood H, Wang L, Erion M, Sherwin R, Kelley DE. GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia. Diabetes 2018, 67: db180031. PMID: 29669745, PMCID: PMC6014553, DOI: 10.2337/db18-0031.Peer-Reviewed Original ResearchConceptsSTZ-diabetic ratsGlucagon secretionGPR119 agonistsGlucagon counterregulatory responseGPR119 knockout miceIntensive insulin therapyInsulin-Induced HypoglycemiaHypoglycemic clamp studiesG protein-coupled receptorsGPR119 agonismIncretin secretionInsulin therapyCounterregulatory responsesDiabetic rodentsHypoglycemic clampIatrogenic hypoglycemiaDiabetic ratsGlucagon releaseKO miceRecurrent boutsAgonist pretreatmentClamp studiesIsolated isletsStimulatory actionCultured islets