Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity
Yao N, Winkler AM, Barrett J, Book GA, Beetham T, Horseman R, Leach O, Hodgson K, Knowles EE, Mathias S, Stevens MC, Assaf M, van Erp TGM, Pearlson GD, Glahn DC. Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity. Human Brain Mapping 2017, 38: 3757-3770. PMID: 28480992, PMCID: PMC6867056, DOI: 10.1002/hbm.23612.Peer-Reviewed Original ResearchConceptsBipolar disorderStructural brain changesCortical thickness reductionsCortical thickness indexHealthy comparison subjectsHum Brain MappCortical thickness measurementsBrain changesLarge cohortNeuroanatomic abnormalitiesPsychotic illnessRegional specificityComparison subjectsFunctional changesSchizophreniaThickness indexCurrent imaging technologiesDisordersGroup structural differencesIllnessSimilar protocolEarlier reportsBiological factorsGroup effectsSpecificity