HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management
Toffanin S, Cornella H, Harrington A, Llovet J, Groszmann R, Iwakiri Y, Taddei T. HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management. Hepatology 2012, 56: 1998-2000. PMID: 23115011, DOI: 10.1002/hep.26080.Peer-Reviewed Original ResearchHepatocellular carcinomaToll-like receptorsIntestinal microbiotaLiver diseaseTranslocation of intestinal bacteriaResident liver cellsAdvanced liver diseaseChronically injured liverHepatocellular carcinoma preventionConsequence of chronic liver injuryTLR-4 signalingChronic liver diseaseChronic liver injuryHepatocellular carcinoma initiationHCC promotionPrevention of apoptosisBacterial translocationTLR-4Liver injuryHepatic inflammationTLR4 activationIncreased proliferationLong-term consequencesTherapeutic targetTLR4