2022
Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort
Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE. Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. Journal Of Hepatology 2022, 76: 1100-1108. PMID: 35066085, PMCID: PMC9018495, DOI: 10.1016/j.jhep.2021.12.034.Peer-Reviewed Original ResearchConceptsChronic liver failureStatin exposureLiver failureStatin useCohort studyChronic liver failure developmentInverse probability treatment weightingProportional hazards regression modelsDoses of statinsVeterans Affairs cohortRetrospective cohort studyChronic liver diseaseHazards regression modelsLarge national cohortVeterans Health AdministrationNumerous beneficial effectsMarginal structural modelsMedian followStatin therapyLiver diseaseNational cohortACLFTreatment weightingCirrhosisPatients
2013
Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence
Bosch J, Groszmann R, Iwakiri Y, Taddei T. Carvedilol for preventing recurrent variceal bleeding: Waiting for convincing evidence. Hepatology 2013, 57: 1665-1667. PMID: 23359118, DOI: 10.1002/hep.26279.Peer-Reviewed Original ResearchCarvedilol groupSevere adverse eventsVariceal bleedingAdverse eventsVariceal rebleedingRecurrent bleedingI groupControl of acute esophageal variceal bleedingPrevention of gastroesophageal variceal rebleedingPreventing recurrent variceal bleedingAcute esophageal variceal bleedingDecrease portal pressureRecurrent upper gastrointestinal bleedingRecurrent variceal bleedingEsophageal variceal bleedingUpper gastrointestinal bleedingMedian followEsophageal varicesGastric varicesPortal pressureGastrointestinal bleedingIsosorbide mononitrateBleedingCarvedilolPatients