2020
Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner.
Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. The Journal Of Immunology 2020, 205: 2008-2015. PMID: 32907997, DOI: 10.4049/jimmunol.1901101.Peer-Reviewed Original ResearchConceptsImmune complexesHealthy miceBone marrowUptake of ICsEndothelial cellsAdministration of erythropoietinSoluble immune complexesLiver reticuloendothelial systemSinusoidal endothelial cellsBone marrow endothelial cellsMarrow endothelial cellsEPO administrationKupffer cellsTransgenic miceAnemic conditionBM erythroblastsReticuloendothelial systemSinusoidal vasculatureMiceBMECsEPO receptorHematopoietic cellsAdministrationEPOHematopoietic niche
2017
Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin
Ito T, Hamazaki Y, Takaori-Kondo A, Minato N. Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin. Cell Structure And Function 2017, 42: 17018. PMID: 29070774, DOI: 10.1247/csf.17018.Peer-Reviewed Original ResearchConceptsBone marrow endothelial cellsMarrow endothelial cellsStromal cellsEndothelial cellsEmergency hematopoiesisBone marrow stromal cellsMature B cellsPhosphorylation of STAT5Immature B cellsSpecific lineagesB cell egressCxcl12 transcriptionMarrow stromal cellsB cell retentionErythropoietin receptorBone marrow microenvironmentBone marrowHematopoietic stemB cellsPrecursor cellsPhenylhydrazine-induced hemolytic anemiaExpression levelsErythropoietin stimulationMesenchymal stromal cellsMarrow microenvironment