2022
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome
Zehentmeier S, Lim VY, Ma Y, Fossati J, Ito T, Jiang Y, Tumanov AV, Lee HJ, Dillinger L, Kim J, Csomos K, Walter JE, Choi J, Pereira JP. Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome. Science Immunology 2022, 7: eabo3170. PMID: 36149943, PMCID: PMC9614684, DOI: 10.1126/sciimmunol.abo3170.Peer-Reviewed Original ResearchConceptsSecondary lymphoid organsWHIM syndromeMesenchymal stem cellsInterleukin-7B lymphopeniaBone marrowBM mesenchymal stem cellsT cell numbersIL-7 productionT-cell lymphopeniaLymphotoxin beta receptorEarly progenitor stageLymphoid organsCell lymphopeniaMouse modelBeta receptorsB cellsB cell developmentLymphopeniaStromal cellsLeukocyte retentionSyndromeGOF mutationsLymphopoietic activityCritical pathways
2020
Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner.
Ito T, Kometani K, Minato N, Hamazaki Y. Bone Marrow Endothelial Cells Take Up Blood-Borne Immune Complexes via Fcγ Receptor IIb2 in an Erythropoietin-Dependent Manner. The Journal Of Immunology 2020, 205: 2008-2015. PMID: 32907997, DOI: 10.4049/jimmunol.1901101.Peer-Reviewed Original ResearchConceptsImmune complexesHealthy miceBone marrowUptake of ICsEndothelial cellsAdministration of erythropoietinSoluble immune complexesLiver reticuloendothelial systemSinusoidal endothelial cellsBone marrow endothelial cellsMarrow endothelial cellsEPO administrationKupffer cellsTransgenic miceAnemic conditionBM erythroblastsReticuloendothelial systemSinusoidal vasculatureMiceBMECsEPO receptorHematopoietic cellsAdministrationEPOHematopoietic niche
2017
Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin
Ito T, Hamazaki Y, Takaori-Kondo A, Minato N. Bone marrow endothelial cells induce immature and mature B cell egress in response to erythropoietin. Cell Structure And Function 2017, 42: 17018. PMID: 29070774, DOI: 10.1247/csf.17018.Peer-Reviewed Original ResearchConceptsBone marrow endothelial cellsMarrow endothelial cellsStromal cellsEndothelial cellsEmergency hematopoiesisBone marrow stromal cellsMature B cellsPhosphorylation of STAT5Immature B cellsSpecific lineagesB cell egressCxcl12 transcriptionMarrow stromal cellsB cell retentionErythropoietin receptorBone marrow microenvironmentBone marrowHematopoietic stemB cellsPrecursor cellsPhenylhydrazine-induced hemolytic anemiaExpression levelsErythropoietin stimulationMesenchymal stromal cellsMarrow microenvironment