Featured Publications
Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.Peer-Reviewed Original Research
2020
CNGA3 acts as a cold sensor in hypothalamic neurons
Feketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons. ELife 2020, 9: e55370. PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/elife.55370.Peer-Reviewed Original Research
2019
A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Zheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels. ELife 2019, 8: e44003. PMID: 30628892, PMCID: PMC6349400, DOI: 10.7554/elife.44003.Peer-Reviewed Original ResearchConceptsPiezo channelsLining inner helixIon channelsMechanosensitive Piezo channelsInner pore helixImportance of inactivationMouse Piezo1Disease-causing mutationsHydrophobic gateInner helixPore helixPhysiological processesMechanism of inactivationStimulation triggersInactivationInactivation gatePiezo1Normal functionHelixHydrophobic barrierFast inactivationPhysical constrictionSecondary gateRate of inactivationMajor determinant
2018
TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels
Anderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN. TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels. Cell Reports 2018, 23: 701-708. PMID: 29669276, PMCID: PMC5929159, DOI: 10.1016/j.celrep.2018.03.094.Peer-Reviewed Original Research
2017
Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters
Matos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters. Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.Peer-Reviewed Original ResearchConceptsTransmembrane domainCold toleranceCold sensitivityGround squirrelsRat orthologMolecular adaptationsMammalian hibernatorsReciprocal mutationsAmino acidsFunctional significanceOrthologsSquirrelsMolecular prerequisitesActive stateHibernatorsTRPM8Somatosensory neuronsTolerancePoor activationSpeciesDomainMutationsResiduesHibernationCellsMolecular basis of tactile specialization in the duck bill
Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAvian ProteinsBeakChickensCloning, MolecularDucksEmbryo, NonmammalianGene ExpressionGenetic VectorsHEK293 CellsHumansIon ChannelsKineticsMechanoreceptorsMechanotransduction, CellularMicePatch-Clamp TechniquesRecombinant ProteinsRNA, Small InterferingSequence Homology, Amino AcidSpecies SpecificityTouchTouch PerceptionTrigeminal GanglionConceptsMolecular basisHeterologous expression systemSpecialist birdsMouse orthologPiezo2 ion channelsTactile specializationExpression systemDuck billMolecular characterizationIon channelsFeeding behaviorEdible matterPiezo2BirdsElectrophysiological characterizationSlow inactivation kineticsOrthologsVertebratesMechanoMechanotransductionKnockdownInactivation kineticsMurky watersHigh densityNeurons