2024
Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice
Tsuzuki A, Yamasaki M, Konno K, Miyazaki T, Takei N, Tomita S, Yuzaki M, Watanabe M. Abundant extrasynaptic expression of α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice. Scientific Reports 2024, 14: 14193. PMID: 38902419, PMCID: PMC11189931, DOI: 10.1038/s41598-024-65076-3.Peer-Reviewed Original ResearchConceptsMHb-IPN pathwayMHb neuronsNicotine dependenceNicotinic acetylcholine receptorsAcetylcholine receptorsNicotine-related behaviorsCell surfaceImmunoelectron microscopySubunitAxonal compartmentFunctional roleNeurotransmitter releasePresynaptic terminalsSubcellular expressionPathwaySimultaneous detectionDistribution patternsSynaptic junctionsNAChRsAnatomical basisExpressionNegative controlReceptorsNeuronsAntibodies
2023
Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior
Park J, Berthoux C, Hoyos-Ramirez E, Shan L, Morimoto-Tomita M, Wang Y, Castillo P, Tomita S. Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior. Cell Reports 2023, 42: 112826. PMID: 37471228, PMCID: PMC10528344, DOI: 10.1016/j.celrep.2023.112826.Peer-Reviewed Original Research
2017
GARLH Family Proteins Stabilize GABAA Receptors at Synapses
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron 2017, 93: 1138-1152.e6. PMID: 28279354, PMCID: PMC5347473, DOI: 10.1016/j.neuron.2017.02.023.Peer-Reviewed Original ResearchConceptsInhibitory transmissionSynaptic transmissionSynaptic localizationInhibitory synaptic transmissionFast inhibitory transmissionFast synaptic transmissionIonotropic neurotransmitter receptorsLigand-gated ion channelsAuxiliary subunitsGABAA receptorsIonotropic GABANeurotransmitter receptorsNeuroligin-2GABAReceptorsAnion channelIon channelsBrainHippocampusFindingsSynapses
2014
Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors
Martenson JS, Tomita S. Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors. Current Opinion In Pharmacology 2014, 20: 102-108. PMID: 25529200, PMCID: PMC4318715, DOI: 10.1016/j.coph.2014.11.011.Peer-Reviewed Original ResearchConceptsSynaptic localizationBasal transmissionGABAA receptorsSynaptic transmissionAMPA receptorsNeurotransmitter receptorsSynaptic plasticityFast synaptic transmissionMultiple receptor subunitsIonotropic neurotransmitter receptorsSynaptic insertionReceptor numberReceptor subunitsReceptorsPrecise mechanismReceptor propertiesAuxiliary subunitsTARP auxiliary subunitsRecent findingsDistinct mechanismsAMPAPostsynapsesPlasticitySynapsesPharmacology
2013
Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability
Brockie PJ, Jensen M, Mellem JE, Jensen E, Yamasaki T, Wang R, Maxfield D, Thacker C, Hoerndli F, Dunn PJ, Tomita S, Madsen DM, Maricq AV. Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability. Neuron 2013, 80: 129-142. PMID: 24094107, PMCID: PMC3795439, DOI: 10.1016/j.neuron.2013.07.028.Peer-Reviewed Original ResearchConceptsGlutamatergic synaptic transmissionGlutamate-gated currentsNervous system functionIonotropic glutamate receptorsC. elegansER exportSynaptic excitabilityCargo adaptorsTransgenic wormsGenetic approachesOpposite phenotypeCornichon ProteinsGlutamate receptorsSynaptic transmissionAgonist AMPAHeterologous cellsAMPA receptorsCentral synapsesAMPAR numberSynaptic communicationReconstitution studies
2010
TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka A, Yan D, Tomita S. TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers. Neuron 2010, 66: 755-767. PMID: 20547132, PMCID: PMC2887694, DOI: 10.1016/j.neuron.2010.04.035.Peer-Reviewed Original ResearchConceptsAMPA receptor activityTransmembrane AMPA receptor regulatory proteinsReceptor activityGlutamate receptorsSynaptic transmissionAMPA receptorsAMPA receptor-mediated synaptic transmissionPredominant excitatory neurotransmitter receptorsReceptor-mediated synaptic transmissionAMPA-type glutamate receptorsSynaptic AMPA receptorsFast synaptic transmissionIonotropic glutamate receptorsExcitatory neurotransmitter receptorsReceptor regulatory proteinsNeuronal activityNeurotransmitter receptorsPSD-95Synaptic strengthNeural circuitsReceptorsPhosphorylation-dependent mannerStargazinSynapsesTarp phosphorylation
2001
PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity
Tomita S, Nicoll R, Bredt D. PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity. Journal Of Cell Biology 2001, 153: f19-f24. PMID: 11381098, PMCID: PMC2174328, DOI: 10.1083/jcb.153.5.f19.Peer-Reviewed Original Research