2000
Overexpression of Human Amyloid Precursor Protein in Drosophila
Yagi Y, Tomita S, Nakamura M, Suzuki T. Overexpression of Human Amyloid Precursor Protein in Drosophila. Archives Of Biochemistry And Biophysics 2000, 4: 43-49. PMID: 11152627, DOI: 10.1006/mcbr.2000.0248.Peer-Reviewed Original ResearchConceptsHuman APPHuman amyloid precursor proteinAPP expression levelsExpression of APPPrecursor proteinAmyloid precursor proteinBeta-amyloid peptideSynaptic terminalsHuman neuronsAlzheimer's diseaseNeural cellsApp functionsExpression levelsDiseasePhysiological functionsProtein transport systemWing blister phenotypePhenotypeWing phenotypeImaginal discsCuticle secretionNeuronsWing tissueProteinSecretionPDZ Domain-dependent Suppression of NF-κB/p65-induced Aβ42 Production by a Neuron-specific X11-like Protein*
Tomita S, Fujita T, Kirino Y, Suzuki T. PDZ Domain-dependent Suppression of NF-κB/p65-induced Aβ42 Production by a Neuron-specific X11-like Protein*. Journal Of Biological Chemistry 2000, 275: 13056-13060. PMID: 10777610, DOI: 10.1074/jbc.c000019200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCell LineCOS CellsDNA, ComplementaryGene Expression RegulationGene LibraryHumansLuciferasesNerve Tissue ProteinsNeuronsNF-kappa BNF-kappa B p50 SubunitPeptide FragmentsPrecipitin TestsProtein BindingProtein IsoformsProtein Structure, TertiaryTranscription Factor RelATranscription, GeneticTransfectionTwo-Hybrid System TechniquesConceptsNF-kappaB/p65X11-like proteinsAlzheimer's diseaseNF-kappaB/p50Progression of ADAmyloid precursor proteinSpecific therapyAbeta productionAβ42 productionAbeta42 productionNF-kappaBP65Neuronal cellsAmino acids 161Precursor proteinX11LAbeta42DiseaseRel homology domainSecretionX11L.P50LIN-10Transcription factorsTherapy
1999
Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer's Amyloid Precursor Protein*
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T. Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer's Amyloid Precursor Protein*. Journal Of Biological Chemistry 1999, 274: 2243-2254. PMID: 9890987, DOI: 10.1074/jbc.274.4.2243.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlzheimer DiseaseAmino Acid SequenceAmyloid beta-Protein PrecursorAnimalsChromosome MappingChromosomes, Human, Pair 9Cloning, MolecularDNA, ComplementaryHumansMolecular Sequence DataNerve Tissue ProteinsNeuronsProtein BindingProtein Processing, Post-TranslationalSequence Homology, Amino Acid