2009
Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study
Palevsky PM, O'Connor TZ, Chertow GM, Crowley ST, Zhang JH, Kellum JA, the US Department of Veterans Affairs/National Institutes of Health Acute Renal Failure Trial Network. Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study. Critical Care 2009, 13: 310. PMID: 19678919, PMCID: PMC2750132, DOI: 10.1186/cc7901.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyAcute Renal Failure Trial Network studyKidney injuryReplacement therapyStudy therapyRenal supportHealth Acute Renal Failure Trial Network studyVeterans Affairs/National InstitutesCause mortalityIll patientsKidney functionContinuous modalitiesStudy investigatorsOptimal doseClinical practiceTherapyVolume managementInjuryNational InstituteNetwork studiesHypotensionPatientsStudy resultsMortality
2008
Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
Palevsky P, Zhang J, O'Connor T, Chertow G, Crowley S, Choudhury D, Finkel K, Kellum J, Paganini E, Schein R, Smith M, Swanson K, Thompson B, Vijayan A, Watnick S, Star R, Peduzzi P. Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. New England Journal Of Medicine 2008, 359: 7-20. PMID: 18492867, PMCID: PMC2574780, DOI: 10.1056/nejmoa0802639.Peer-Reviewed Original ResearchConceptsAcute kidney injuryRenal replacement therapyNonrenal organ failureContinuous venovenous hemodiafiltrationIntensive treatment strategiesKidney injuryIll patientsIntensive therapyIntermittent hemodialysisKidney functionOrgan failureRenal supportTreatment strategiesContinuous renal replacement therapyDay 60Intensive renal replacement therapyIntensive renal supportLow-efficiency dialysisCritically Ill PatientsPrimary end pointHemodialysis three timesRate of deathNonrenal organsBaseline characteristicsStable patients