2016
A nucleolar role for the Fanconi anemia pathway protein, FANCI, in rDNA transcription
Sondalle S, Longerich S, Sung P, Baserga S. A nucleolar role for the Fanconi anemia pathway protein, FANCI, in rDNA transcription. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1048.1.Peer-Reviewed Original ResearchRNA polymerase IRibosome biogenesisDNA repairFanconi anemiaNucleolar proteinsNucleolar roleHeLa cell nuclear extractsPre-ribosomal RNANovel regulatory mechanismCell nuclear extractsDNA repair defectsInterstrand DNA crosslinksMature ribosomesRDNA transcriptionRRNA transcriptionLarge subunitNucleolar functionFA proteinsFANCIUbiquitination stateSubcellular fractionationReduced transcriptionPolymerase IBiogenesisRegulatory mechanisms
2013
NOL11, implicated in the pathogenesis of North American Indian Childhood Cirrhosis, is required for pre‐rRNA transcription and processing
Baserga S, Freed E, Prieto J, McCann K, McStay B. NOL11, implicated in the pathogenesis of North American Indian Childhood Cirrhosis, is required for pre‐rRNA transcription and processing. The FASEB Journal 2013, 27: 552.1-552.1. DOI: 10.1096/fasebj.27.1_supplement.552.1.Peer-Reviewed Original ResearchNorth American Indian childhood cirrhosisRibosome biogenesisSmall subunitC-terminusInteraction partnersDefective protein-protein interactionsTwo-hybrid cDNA libraryUncharacterized nucleolar proteinRibosome biogenesis factorsRibosome biogenesis defectsTwo-hybrid analysisPre-rRNA transcriptionRibosomal small subunitProtein-protein interactionsCo-immunoprecipitation experimentsRDNA transcriptionBiogenesis defectsBiogenesis factorsNucleolar proteinsNovel proteinCDNA libraryCirhinAffinity purificationDisease mutationsSiRNA knockdown