2024
The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis
McCool M, Bryant C, Abriola L, Surovtseva Y, Baserga S. The cytidine deaminase APOBEC3A regulates nucleolar function to promote cell growth and ribosome biogenesis. PLOS Biology 2024, 22: e3002718. PMID: 38976757, PMCID: PMC11257408, DOI: 10.1371/journal.pbio.3002718.Peer-Reviewed Original ResearchRibosome biogenesis factorsRibosome biogenesisBiogenesis factorsCell growthNucleolar functionRegulation of nucleolar functionHuman ribosome biogenesisProtein synthesisProduction of ribosomesFamily of proteinsSource of mutagenesisLevel of protein synthesisCytidine deaminase familyIncreased cell growthPromote cell growthPre-rRNAPotential direct rolePre-mRNATransient overexpressionRibosomeGenomic mutationsBiogenesisMCF10A cellsMaturation stepsAPOBEC3A
2020
Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver
Farley‐Barnes K, Baserga S. Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver. 2020, 174-182. DOI: 10.1002/9781119436812.ch15.ChaptersRibosome biogenesisBiogenesis of ribosomesProduction of ribosomesHuman ribosome biogenesisCell growthTumor suppressor p53Cellular cuesNumerous proteinsNucleolar stressRegulated processTranscription factorsBiogenesisNutrient availabilityKey regulatorMechanistic targetSuppressor p53Rapamycin (mTOR) pathwayRibosomesRegulationProliferationSuch diseasesMYCRegulatorCytoplasmProtein
2015
Determinants of mammalian nucleolar architecture
Farley KI, Surovtseva Y, Merkel J, Baserga SJ. Determinants of mammalian nucleolar architecture. Chromosoma 2015, 124: 323-331. PMID: 25670395, PMCID: PMC4534358, DOI: 10.1007/s00412-015-0507-z.Peer-Reviewed Original ResearchConceptsNucleolar formationNucleolar architectureNucleolar structureNucleolar organizer regionsProduction of ribosomesRibosome biogenesisFunctional nucleoliHuman nucleoliCell divisionOrganizer regionsNucleoliEssential machineFunction manifestBiogenesisIntricate relationshipMinimal requirementsCellsRibosomesOrganellesProteinFunctionFormationDivisionDeterminants