2017
Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study
Singh K, Trivedi R, Verma A, D'souza M, Koundal S, Rana P, Baishya B, Khushu S. Altered metabolites of the rat hippocampus after mild and moderate traumatic brain injury – a combined in vivo and in vitro 1H–MRS study. NMR In Biomedicine 2017, 30 PMID: 28759166, DOI: 10.1002/nbm.3764.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryDay 1Metabolic alterationsDay 5Moderate traumatic brain injuryPathological processesN-acetylaspartate levelsTrauma-induced changesSeverity of injuryProton magnetic resonance spectroscopy dataRat hippocampusGlutamine/glutamateHippocampus regionTBI groupAltered metabolitesHigher cognitive functionsCognitive functionInjuryMetabolic irregularitiesAmino acid metabolismCitric acid cycle intermediatesAltered levelsMetabolic profileOxidative stress
2015
“Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia
Koundal S, Gandhi S, Kaur T, Mazumder A, Khushu S. “Omics” of High Altitude Biology: A Urinary Metabolomics Biomarker Study of Rats Under Hypobaric Hypoxia. OMICS A Journal Of Integrative Biology 2015, 19: 757-765. PMID: 26669710, DOI: 10.1089/omi.2015.0155.Peer-Reviewed Original ResearchConceptsHypobaric hypoxiaSports medicineHypobaric hypoxia exposurePreclinical rat modelHigh altitude medicineAltitude medicineCell membrane metabolismUse of metabolomicsUrinary metabolomeHepatic functionLiver histopathologyRat modelLiver functioningHypoxia exposureHealth problemsMultivariate analysisPotential biomarkersAttendant health problemsTCA cycle metabolitesBiomarker studiesHypoxiaUrine samplesTaurine metabolismMembrane metabolismCycle metabolites
2014
Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T
Koundal S, Gandhi S, Kaur T, Khushu S. Neurometabolic and structural alterations in rat brain due to acute hypobaric hypoxia: in vivo 1H MRS at 7 T. NMR In Biomedicine 2014, 27: 341-347. PMID: 24395642, DOI: 10.1002/nbm.3068.Peer-Reviewed Original ResearchConceptsAcute hypobaric hypoxiaHypobaric hypoxiaRat brainHH exposureCA2/CA3 regionDays of normoxiaMetabolite levelsProcess of demyelinationMyo-inositol levelsDays post exposureVivo 1H MRSEarly risk assessmentGlutamatergic neuronsNeurometabolic changesAstrocyte metabolismCA3 regionN-acetylaspartateHippocampus regionMetabolic alterationsPost exposureMetabolic changesNormoxiaBrainFourth dayFirst day