2022
A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes
Reiss AL, Jo B, Arbelaez AM, Tsalikian E, Buckingham B, Weinzimer SA, Fox LA, Cato A, White NH, Tansey M, Aye T, Tamborlane W, Englert K, Lum J, Mazaika P, Foland-Ross L, Marzelli M, Mauras N. A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes. Nature Communications 2022, 13: 4940. PMID: 36042217, PMCID: PMC9427757, DOI: 10.1038/s41467-022-32289-x.Peer-Reviewed Original ResearchConceptsHybrid closed-loop insulin delivery systemStandard care groupType 1 diabetesClosed-loop insulin delivery systemWhite matter volumeCare groupPrimary outcomeInsulin delivery systemsMatter volumeFractional anisotropyCognitive AssessmentRigorous glucose controlDiagnosis of T1DClosed-loop groupBetter diabetes controlDiabetes care groupsConcept pilot studyYears of ageAcademic medical centerFunctional brain activityCortical surface areaMonths study durationRandomized participantsDiabetes controlGlucose control
2020
Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory
Foland-Ross LC, Tong G, Mauras N, Cato A, Aye T, Tansey M, White NH, Weinzimer SA, Englert K, Shen H, Mazaika PK, Reiss AL, Tsalikian E, Tansey M, Coffey J, Cabbage J, Salamat S, Bisbee R, Mauras N, Fox L, Cato A, Englert K, Sikes K, Ewen T, Bird K, Buckingham B, Wilson D, Aye T, Kingman R, Weinzimer S, Tamborlane W, Ambrosino J, Steffen A, Weyman K, Zgorski M, White N, Arbelaez A, Levandoski L, Starnes A, Hershey T, Reiss A, Foland-Ross L, Marzelli M, Mazaika P, Tong G, Sperling M, Becker D, Cleary P, Greenbaum C, Moran A. Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory. Diabetes 2020, 69: 1770-1778. PMID: 32471809, PMCID: PMC7372069, DOI: 10.2337/db20-0123.Peer-Reviewed Original ResearchConceptsType 1 diabetesImproved glycemic controlBrain function differencesFunctional MRI studyGreater modulationDiabetes groupGlycemic controlFrontoparietal cortexMRI studiesControl groupDiabetesType 1Functional MRICompensatory mechanismsEarly onsetBrain activationVisuospatial Working Memory TaskChildrenN-back taskMemory functionEarly ageMemory abilityWorking Memory TaskFuture studiesActivation
2018
Impact of Early Diabetic Ketoacidosis on the Developing Brain
Aye T, Mazaika PK, Mauras N, Marzelli MJ, Shen H, Hershey T, Cato A, Weinzimer SA, White NH, Tsalikian E, Jo B, Reiss AL, Group D, Tsalikian E, Tansey M, Coffey J, Cabbage J, Salamati S, Mauras N, Fox L, Cato A, Englert K, Sikes K, Buckingham B, Wilson D, Aye T, Caswell K, Ambers E, Weinzimer S, Tamborlane W, Steffen A, Weyman K, Zgorski M, Ambrosino J, White N, Arbelaez A, Levandoski L, Starnes A, Hershey T, Reiss A, Barnea-Goraly N, Marzelli M, Mazaika P, Peng D, Beck R, Kollman C, Ruedy K, Winer K, Sperling M, Becker D, Cleary P, Greenbaum C, Moran A. Impact of Early Diabetic Ketoacidosis on the Developing Brain. Diabetes Care 2018, 42: dc181405. PMID: 30573652, PMCID: PMC6385695, DOI: 10.2337/dc18-1405.Peer-Reviewed Original Research
2016
Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Saggar M, Tsalikian E, Mauras N, Mazaika P, White NH, Weinzimer S, Buckingham B, Hershey T, Reiss AL. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes. Diabetes 2016, 66: 754-762. PMID: 27702833, PMCID: PMC5319714, DOI: 10.2337/db16-0414.Peer-Reviewed Original ResearchConceptsControl subjectsIntrinsic connectivityAge-matched control subjectsYoung childrenBrain intrinsic connectivityResting-state functional MRI dataType 1 diabetesSeed-based analysisCognitive functioningBlood glucoseSustained dysregulationOverall group differencesLarge multisite studyT1DYounger ageFunctional MRI dataCognitive deficitsType 1Cognitive functionObserved positive associationDiabetesMultisite studyCompensatory roleGroup differencesBrain