2009
Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*
Tommasini SM, Hu B, Nadeau JH, Jepsen KJ. Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae*. Journal Of Bone And Mineral Research 2009, 24: 606-620. PMID: 19063678, PMCID: PMC2659510, DOI: 10.1359/jbmr.081224.Peer-Reviewed Original ResearchConceptsQuantitative trait lociBody sizeBone traitsPhenotypic integrationTrait covariationComplex traitsTrait lociMultiple traitsGenetic analysisDifferent traitsEnvironmental perturbationsSkeletal traitsTrabecular traitsAXB/BXAC57BL/6J genomeRI panelNonrandom setTraitsCompensatory interactionsGenetic variantsAdaptive responseB6 genomeRelative amountsGenomeCompositional traits
2008
Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains
Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Cordova M, Nadeau JH. Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains. Mammalian Genome 2008, 20: 21. PMID: 19082857, PMCID: PMC2650248, DOI: 10.1007/s00335-008-9158-1.Peer-Reviewed Original ResearchConceptsGenetic variantsSkeletal traitsFunctional interactionMatrix mineralizationCompensatory interactionsGenotype-phenotype relationshipsPhenotypic integrationAdult traitsLoss of functionBiological controlPrecise regulationMouse strainsAXB/BXASusceptibility genesInner bone surfaceTraitsEnvironmental variantsPostnatal growthNew insightsBone slendernessQuantitative expectationsVariantsGrowthSkeletal growthExpansion rateBiological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*
Tommasini SM, Nasser P, Hu B, Jepsen KJ. Biological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*. Journal Of Bone And Mineral Research 2008, 23: 236-246. PMID: 17922614, PMCID: PMC2665697, DOI: 10.1359/jbmr.071014.Peer-Reviewed Original Research
2007
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mammalian Genome 2007, 18: 492-507. PMID: 17557179, PMCID: PMC1998883, DOI: 10.1007/s00335-007-9017-5.Peer-Reviewed Original ResearchConceptsFunctional interactionMean trait valuesRI strainsCombination of traitsTrait valuesGenomic regionsCellular processesLoss of functionBone slendernessGenetic variabilityEnvironmental perturbationsSkeletal traitsAXB/BXAImportant functional interactionTraitsBiological paradigmBone traitsFunctional relationshipMouse strainsGenetic randomizationAdult malesHigher mineral densityStrainsUnique setGrowth
2005
Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*
Tommasini SM, Morgan TG, van der Meulen MCh, Jepsen KJ. Genetic Variation in Structure‐Function Relationships for the Inbred Mouse Lumbar Vertebral Body*. Journal Of Bone And Mineral Research 2005, 20: 817-827. PMID: 15824855, DOI: 10.1359/jbmr.041234.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBiomechanical PhenomenaBone and BonesFemaleGenetic VariationLumbar VertebraeMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsModels, AnatomicModels, BiologicalModels, GeneticMultivariate AnalysisPhenotypeSpecies SpecificityStress, MechanicalStructure-Activity RelationshipTensile StrengthTomography, X-Ray ComputedConceptsMechanical propertiesBone mechanical propertiesTrabecular bone tissueWhole bone mechanical propertiesMeasure of ductilityTotal deformationFailure loadVertebral mechanical propertiesBone tissueIsotropic voxel sizeBiomechanical analysisImaging systemPropertiesDuctilityStructure-function relationshipsVoxel sizeDeformationBV/TVStiffness