2023
Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageHumansIschemic StrokeMagnetic Resonance ImagingStrokeTomography, X-Ray ComputedPortable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions.
Hong C, Lamsam L, Yadlapalli V, Parasuram N, Mazurek M, Chavva I, Lalwani D, Zabinska J, Schiff S, Manes R, Vining E, Rimmer R, Kimberly W, Sheth K, Omay S. Portable MRI to assess optic chiasm decompression after endoscopic endonasal resection of sellar and suprasellar lesions. Journal Of Neurosurgery 2023, 139: 1664-1670. PMID: 37347618, DOI: 10.3171/2023.5.jns23174.Peer-Reviewed Original ResearchMeSH KeywordsDecompressionHumansMagnetic Resonance ImagingOptic ChiasmPituitary NeoplasmsReproducibility of ResultsRetrospective StudiesConceptsEndoscopic endonasal surgeryOptic nerve decompressionEndonasal surgerySuprasellar lesionsNerve decompressionOptic chiasmThird ventricleConventional MRIOptic chiasm compressionEndoscopic endonasal resectionChiasm compressionPreoperative imagingSingle institutionEndonasal resectionMRI availabilityRoutine MRISignificant interrater reliabilitySuprasellar pathologiesSurgeryNeurosurgical oncologyLinear mixed-effects modelsPortable MRIPatientsMRIMixed-effects modelsIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexOn‐site construction of a point‐of‐care low‐field MRI system in Africa
Obungoloch J, Muhumuza I, Teeuwisse W, Harper J, Etoku I, Asiimwe R, Tusiime P, Gombya G, Mugume C, Namutebi M, Nassejje M, Nayebare M, Kavuma J, Bukyana B, Natukunda F, Ninsiima P, Muwanguzi A, Omadi P, van Gijzen M, Schiff S, Webb A, O'Reilly T. On‐site construction of a point‐of‐care low‐field MRI system in Africa. NMR In Biomedicine 2023, 36: e4917. PMID: 36914258, PMCID: PMC10330026, DOI: 10.1002/nbm.4917.Peer-Reviewed Original ResearchFuture of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI
Parasuram N, Crawford A, Mazurek M, Chavva I, Beekman R, Gilmore E, Petersen N, Payabvash S, Sze G, Eugenio Iglesias J, Omay S, Matouk C, Longbrake E, de Havenon A, Schiff S, Rosen M, Kimberly W, Sheth K. Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI. Neurology 2023, 100: 1067-1071. PMID: 36720639, PMCID: PMC10259275, DOI: 10.1212/wnl.0000000000207074.Peer-Reviewed Original Research
2021
Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid
Peterson M, Cherukuri V, Paulson J, Ssentongo P, Kulkarni A, Warf B, Monga V, Schiff S. Normal childhood brain growth and a universal sex and anthropomorphic relationship to cerebrospinal fluid. Journal Of Neurosurgery Pediatrics 2021, 28: 458-468. PMID: 34243147, PMCID: PMC8594737, DOI: 10.3171/2021.2.peds201006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsAnalysis of VarianceAnthropometryBody WeightBrainCerebrospinal FluidChildChild DevelopmentChild, PreschoolCohort StudiesFemaleFunctional LateralityHumansHydrocephalusInfantInfant, NewbornMagnetic Resonance ImagingMaleOrgan SizePopulationReference StandardsSex CharacteristicsConceptsBrain growthBrain volumeFluid accumulationRatio of brainHealthy pediatric subjectsTotal brain volumeAge 18 yearsYears of ageRegional brain volumesNormal brain growthAge-dependent relationshipCSF accumulationPediatric subjectsChildhood diseasesCerebrospinal fluidCSF volumeCongenital disorderVolume trajectoriesEarly childhoodNormative growth curvesNumerous conditionsSexMagnetic resonanceBrain size
2018
Design of a sustainable prepolarizing magnetic resonance imaging system for infant hydrocephalus
Obungoloch J, Harper J, Consevage S, Savukov I, Neuberger T, Tadigadapa S, Schiff S. Design of a sustainable prepolarizing magnetic resonance imaging system for infant hydrocephalus. Magnetic Resonance Materials In Physics, Biology And Medicine 2018, 31: 665-676. PMID: 29644479, PMCID: PMC6135672, DOI: 10.1007/s10334-018-0683-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebrospinal FluidContrast MediaEquipment DesignHumansHydrocephalusInfantMagnetic Resonance ImagingPhantoms, ImagingRadio WavesSignal-To-Noise RatioConceptsLow power requirementsSpatial resolutionLF-MRIModest spatial resolutionMagnetic resonance imaging systemPower requirementsCoil systemImage spatial resolutionUnshielded environmentGradient fieldResonance imaging systemLow costDeployment potentialEnergy supplySpecific applicationsUnshielded roomImaging systemLow-field magnetic resonance imagingNormative human brain volume growth.
Peterson M, Warf B, Schiff S. Normative human brain volume growth. Journal Of Neurosurgery Pediatrics 2018, 21: 478-485. PMID: 29498607, PMCID: PMC6212293, DOI: 10.3171/2017.10.peds17141.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingBiostatisticsBrainChildChild, PreschoolFemaleGrowth ChartsHumansInfantInfant, NewbornMagnetic Resonance ImagingMaleModels, BiologicalOrgan SizeConceptsStatistical measuresPower lawNonlinear least-squares regression algorithmGood statistical resultsLeast squares regression algorithmCurve fitCandidate modelsCorresponding statisticsAppropriate statistical measuresFit parametersStatistical resultsRegression algorithmWeibull fitWeibull modelNormative MRI dataPotential modelFitVolume growthGompertz modelBest modelModelModel curve fitWeibullLawStatistics
2016
Design of a mobile, homogeneous, and efficient electromagnet with a large field of view for neonatal low-field MRI
Lother S, Schiff S, Neuberger T, Jakob P, Fidler F. Design of a mobile, homogeneous, and efficient electromagnet with a large field of view for neonatal low-field MRI. Magnetic Resonance Materials In Physics, Biology And Medicine 2016, 29: 691-698. PMID: 26861046, PMCID: PMC5695548, DOI: 10.1007/s10334-016-0525-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnanasComputer SimulationEquipment DesignHeadHumansInfant, NewbornMagnetic FieldsMagnetic Resonance ImagingMagneticsMagnetsSignal-To-Noise RatioSteelConceptsCryogen-free systemField mapping measurementsHigh B0 fieldsLow field devicesLow power consumptionSteel platesLight weightMagnetic resonance imaging systemSimple fabricationNumerical optimization algorithmHomogeneous magnetic fieldPower consumptionElectromagnetResonance imaging systemPower useB0 fieldLow-field scannersMagnetic fieldLow-field MRIField strengthHigh homogeneityMedical applicationsField limitationsLarge fieldMagnets
2014
Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images.
Mandell J, Langelaan J, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 1. Particle filter segmentation of brain and cerebrospinal fluid growth dynamics from MRI and CT images. Journal Of Neurosurgery Pediatrics 2014, 15: 113-24. PMID: 25431902, DOI: 10.3171/2014.9.peds12426.Peer-Reviewed Original ResearchConceptsEdge trackerParticle filterGround vehicle navigationBrain image analysisCT imagesMRI data setsImage segmentationSegmentation algorithmAutonomous airVehicle navigationAccurate edgesNovel algorithmManual segmentationSegmentationMR imagesBrain dataVolumetric brain analysisData setsImage analysisSemiautomatic methodImagesModality independenceHistorical dataAlgorithmMRI dataVolumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus.
Mandell J, Kulkarni A, Warf B, Schiff S. Volumetric brain analysis in neurosurgery: Part 2. Brain and CSF volumes discriminate neurocognitive outcomes in hydrocephalus. Journal Of Neurosurgery Pediatrics 2014, 15: 125-32. PMID: 25431901, DOI: 10.3171/2014.9.peds12427.Peer-Reviewed Original ResearchConceptsFrontal-occipital horn ratioNeurocognitive outcomesBrain volumeCSF volumeFluid volumePediatric patientsBrain developmentEvaluation of hydrocephalusGoal of treatmentSmaller brain volumesLower cognitive outcomesPoor neurocognitive outcomesNormal brain developmentLarge fluid volumesHealthy brain developmentVolumetric brain analysisSurgical treatmentVentricular sizeHydrocephalic patientsCT scanHydrocephalusPatientsBayley ScalesBrain growthFine motorVolumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy.
Mandell J, Hill K, Nguyen D, Moser K, Harbaugh R, McInerney J, Nsubuga B, Mugamba J, Johnson D, Warf B, Boling W, Webb A, Schiff S. Volumetric brain analysis in neurosurgery: Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy. Journal Of Neurosurgery Pediatrics 2014, 15: 133-43. PMID: 25431899, DOI: 10.3171/2014.9.peds12428.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnterior Temporal LobectomyBrainCerebrospinal FluidChildChild, PreschoolCognitionCone-Beam Computed TomographyEpilepsy, Temporal LobeFemaleFrontal LobeHumansHydrocephalusInfantMagnetic Resonance ImagingMaleNeurosurgical ProceduresOccipital LobeOrgan SizePredictive Value of TestsSeizuresTreatment OutcomeUgandaConceptsTemporal lobe volumeMesial temporal sclerosisTemporal lobe epilepsyTemporal lobe resectionSeizure outcomeTemporal lobeVolumetric CT analysisBrain volumeLobe volumeSeizure controlStructural MRILobe resectionEngel class Ia outcomeClass Ia outcomeSelection of patientsCT volumetric analysisPreoperative CT scanSmaller brain volumesSmaller temporal lobeCURE Children's HospitalIncomplete seizure controlNormalized brain volumeWhole brain volumeCT analysisTemporal lobe structures
2010
The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice.
Mandell J, Neuberger T, Drapaca C, Webb A, Schiff S. The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice. Journal Of Neurosurgery Pediatrics 2010, 6: 1-10. PMID: 20593980, DOI: 10.3171/2010.4.peds1014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlgorithmsAnimalsAnimals, NewbornBrainCephalometryCerebral AqueductCerebral VentriclesDisease Models, AnimalFourier AnalysisFrontal LobeHydrocephalusImage Processing, Computer-AssistedImaging, Three-DimensionalIntracranial PressureLateral VentriclesMagnetic Resonance ImagingMathematical ComputingMiceMice, Inbred C57BLOccipital LobeOrgan SizeReference ValuesConceptsHydrocephalic miceBrain volumeClinical outcomesBrain growthVentricle volumeDynamics of brainCortical mantle thicknessPatterns of hydrocephalusOccipital horn ratioAccumulation of CSFTransmantle pressure gradientGrowth of brainVentricular ruptureParenchymal edemaVentricular sizeC57BL/6 miceTotal brainPercutaneous injectionAdjunct useHead circumferenceNormal miceCisterna magnaCSF volumeCognitive functionSerial quantification
2009
Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit
Schachter S, Guttag J, Schiff S, Schomer D, Contributors S. Advances in the Application of Technology to Epilepsy: The CIMIT/NIO Epilepsy Innovation Summit. Epilepsy & Behavior 2009, 16: 3-46. PMID: 19780225, PMCID: PMC8118381, DOI: 10.1016/j.yebeh.2009.06.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnticonvulsantsBrain MappingChildDrug ResistanceElectric Stimulation TherapyElectroencephalographyEngineeringEpilepsyHumansMagnetic Resonance ImagingMedical Laboratory ScienceMicroelectrodesNanoparticlesNeuronsNeurosurgeryNeurotoxinsPredictive Value of TestsSeizuresSpectroscopy, Near-InfraredTomography, Emission-Computed, Single-PhotonTomography, OpticalTranscranial Magnetic StimulationConceptsTreatment systemEvaluation of patientsTreatment of patientsGroup of cliniciansEpilepsy surgeryEngineering technologyFurther technological developmentEpilepsySeizure onset detectionPatientsEngineersSeizure predictionTechnologyApplicationsOnset detectionSurgeryCliniciansPhysiciansUnmetDiagnosis
2002
Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease.
Schiff S, Dunagan B, Worth R. Failure of single-unit neuronal activity to differentiate globus pallidus internus and externus in Parkinson disease. Journal Of Neurosurgery 2002, 97: 119-28. PMID: 12134901, DOI: 10.3171/jns.2002.97.1.0119.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAgedBrain MappingElectrophysiologyGlobus PallidusHumansMagnetic Resonance ImagingMicroelectrodesMiddle AgedNeuronsParkinson DiseaseConceptsGlobus pallidus internusSingle-unit activityParkinson's diseaseNeuronal activitySingle-unit neuronal activitySingle unit neuronal recordingsFinal electrode placementElectrode placementMean firing frequencyTotal spectral powerPallidal surgeryMicroelectrode recordingsFiring frequencyOperating roomNeuronal recordingsInternusDiseaseExternusSpectral powerRecordingsPallidotomyPatientsSurgeryLesionsActivity
1997
Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study.
Hertz-Pannier L, Gaillard W, Mott S, Cuenod C, Bookheimer S, Weinstein S, Conry J, Papero P, Schiff S, Bihan D, Theodore W. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997, 48: 1003-12. PMID: 9109891, DOI: 10.1212/wnl.48.4.1003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainBrain MappingChildDominance, CerebralEpilepsies, PartialFeasibility StudiesFemaleHumansMagnetic Resonance ImagingMaleVerbal BehaviorConceptsFunctional magnetic resonance imagingElectrostimulation mappingLeft dominanceFunctional mapping techniquesMagnetic resonance imagingNoninvasive functional mappingRight-handed childrenLanguage dominanceBilateral languageHemodynamic changesEpilepsy surgeryPartial epilepsySurgery outcomesTemporal epilepsyAmobarbital testNeuronal activationWord generation taskFrontal lobeLanguage lateralizationRight dominanceNoninvasive assessmentResonance imagingFunctional MRISignal time courseBrain development
1995
FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation
Gaillard W, White S, MalOw B, Flamini R, Weinstein S, Sato S, Kufta C, Schiff S, Devinsky O, Fazilat S, Reeves P, Theodore W. FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery,evaluation. Epilepsy Research 1995, 20: 77-84. PMID: 7713062, DOI: 10.1016/0920-1211(94)00065-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetChildElectroencephalographyEpilepsy, Complex PartialGlucoseHumansMagnetic Resonance ImagingSeizuresTomography, Emission-ComputedTreatment OutcomeConceptsComplex partial seizuresEEG fociPartial seizuresFDG-PETEpileptic focusGlucose metabolismRefractory complex partial epilepsyFocal MRI abnormalitiesInterictal glucose metabolismUnilateral EEG focusFDG-PET resultsFDG-PET hypometabolismComplex partial epilepsyFocal hypometabolismPET hypometabolismMRI abnormalitiesMetabolic abnormalitiesEpilepsy surgerySurgical interventionPartial epilepsyVideo-EEGEpileptogenic zonePoor responseRegional hypometabolismDrug treatment