2014
Oxygen and seizure dynamics: I. Experiments
Ingram J, Zhang C, Cressman J, Hazra A, Wei Y, Koo Y, Žiburkus J, Kopelman R, Xu J, Schiff S. Oxygen and seizure dynamics: I. Experiments. Journal Of Neurophysiology 2014, 112: 205-212. PMID: 24598521, PMCID: PMC4064411, DOI: 10.1152/jn.00540.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA1 Region, HippocampalMaleOxygenPyramidal CellsRatsRats, Sprague-DawleySeizuresConceptsEpileptiform activityRat hippocampal slicesLayer-specific patternsSeizure-like eventsSeizure-like stateSpontaneous seizure-like eventsHippocampal slicesSeizure onsetNeuronal interplayCellular excitabilitySeizure dynamicsEndogenous hypoxiaGreater reductionO2 utilizationHypoxiaElectrical recordingsSeizuresCA1ExcitabilityPyramidale
2013
FRET excited ratiometric oxygen sensing in living tissue
Ingram J, Zhang C, Xu J, Schiff S. FRET excited ratiometric oxygen sensing in living tissue. Journal Of Neuroscience Methods 2013, 214: 45-51. PMID: 23333398, PMCID: PMC3664065, DOI: 10.1016/j.jneumeth.2013.01.002.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsColoring AgentsComputer SystemsConvulsantsFluorescence Resonance Energy TransferGlassHippocampusIn Vitro TechniquesLuminescent MeasurementsMetal NanoparticlesMicroelectrodesOrganoplatinum CompoundsOximetryOxygen ConsumptionPorphyrinsPyramidal CellsQuantum DotsRatsRats, Sprague-DawleySingle-Cell AnalysisConceptsInterstitial oxygen concentrationGlass substratesPolymer matrixBiocompatible sensorsInert polymer matrixDynamic analysisOptical sensorsMatrix consistingTemporal resolutionSensorsMillisecond temporal resolutionOxygen concentrationQuantum dotsMatrixRatiometric oxygenFluorescence resonance energy transferEnergy transfer
2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell types
2006
Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events
Ziburkus J, Cressman J, Barreto E, Schiff S. Interneuron and Pyramidal Cell Interplay During In Vitro Seizure-Like Events. Journal Of Neurophysiology 2006, 95: 3948-3954. PMID: 16554499, PMCID: PMC1469233, DOI: 10.1152/jn.01378.2005.Peer-Reviewed Original Research
2003
Sensitivity of Neurons to Weak Electric Fields
Francis J, Gluckman B, Schiff S. Sensitivity of Neurons to Weak Electric Fields. Journal Of Neuroscience 2003, 23: 7255-7261. PMID: 12917358, PMCID: PMC6740448, DOI: 10.1523/jneurosci.23-19-07255.2003.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCells, CulturedElectric StimulationElectricityNerve NetNeuronsPyramidal CellsRatsRats, Sprague-Dawley
2002
Decreased Neuronal Synchronization during Experimental Seizures
Netoff T, Schiff S. Decreased Neuronal Synchronization during Experimental Seizures. Journal Of Neuroscience 2002, 22: 7297-7307. PMID: 12177225, PMCID: PMC6757884, DOI: 10.1523/jneurosci.22-16-07297.2002.Peer-Reviewed Original Research
1998
Periodic Orbits: A New Language for Neuronal Dynamics
So P, Francis J, Netoff T, Gluckman B, Schiff S. Periodic Orbits: A New Language for Neuronal Dynamics. Biophysical Journal 1998, 74: 2776-2785. PMID: 9635732, PMCID: PMC1299619, DOI: 10.1016/s0006-3495(98)77985-8.Peer-Reviewed Original Research