2024
Paediatric hydrocephalus
Kahle K, Klinge P, Koschnitzky J, Kulkarni A, MacAulay N, Robinson S, Schiff S, Strahle J. Paediatric hydrocephalus. Nature Reviews Disease Primers 2024, 10: 35. PMID: 38755194, DOI: 10.1038/s41572-024-00519-9.Peer-Reviewed Original ResearchConceptsSymptoms of elevated intracranial pressureCerebrospinal fluidCentral nervous system infectionChoroid plexus cauterizationEndoscopic third ventriculostomyNervous system infectionNonsurgical treatment strategiesElevated intracranial pressureLong-term outcomesNeural tube defectsCSF-brain interfaceFetal hydrocephalusUtero treatmentAcquired hydrocephalusCSF secretionSurgical closureCSF shuntingHead circumferenceThird ventriculostomyCongenital hydrocephalusAssociated with blockageGene mutationsCerebral ventricleTreatment strategiesCSF pathwaysThe genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Hale A, Boudreau H, Devulapalli R, Duy P, Atchley T, Dewan M, Goolam M, Fieggen G, Spader H, Smith A, Blount J, Johnston J, Rocque B, Rozzelle C, Chong Z, Strahle J, Schiff S, Kahle K. The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact. Fluids And Barriers Of The CNS 2024, 21: 24. PMID: 38439105, PMCID: PMC10913327, DOI: 10.1186/s12987-024-00513-z.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidOverview of genesEtiology of HCPathogenesis of HCChoroid plexus cauterizationEndoscopic third ventriculostomyIncreased intracranial pressureGenetic architectureGenetic basisImpact of geneticsVentricular shuntSurgical treatmentThird ventriculostomyPhenotypic heterogeneityHeterogeneous diseasePharmacological treatmentGenetic syndromesMolecular pathogenesisIntracranial pressureHydrocephalusTherapeutic measuresGenesGeneticsBrain injuryPathway
2021
Brain growth after surgical treatment for infant postinfectious hydrocephalus in Sub-Saharan Africa: 2-year results of a randomized trial.
Schiff S, Kulkarni A, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, Cherukuri V, Warf B. Brain growth after surgical treatment for infant postinfectious hydrocephalus in Sub-Saharan Africa: 2-year results of a randomized trial. Journal Of Neurosurgery Pediatrics 2021, 28: 326-334. PMID: 34243157, PMCID: PMC8742836, DOI: 10.3171/2021.2.peds20949.Peer-Reviewed Original ResearchPostinfectious hydrocephalusSurgical treatmentBrain volumeBrain growthBSID-III cognitive scoresMajor public health burdenSurgical treatment armSuccessful surgical treatmentBrain volume lossBrain volume changesEndoscopic third ventriculostomyFraction of patientsPublic health burdenChoroid plexus cauterizationBSID-III scoresNormal brain volumePostinfectious etiologySingle centerSub-Saharan AfricaTreatment armsThird ventriculostomyInfection preventionHealth burdenCT scanHydrocephalus
2019
The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial.
Punchak M, Mbabazi Kabachelor E, Ogwal M, Nalule E, Nalwoga J, Ssenyonga P, Mugamba J, Rattani A, Dewan M, Kulkarni A, Schiff S, Warf B. The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial. Neurosurgery 2019, 85: e714-e721. PMID: 31086941, PMCID: PMC7534394, DOI: 10.1093/neuros/nyz122.Peer-Reviewed Original ResearchConceptsChoroid plexus cauterizationETV/CPCPostoperative seizure incidencePostinfectious hydrocephalusSeizure incidenceEndoscopic third ventriculostomyUgandan infantsShunt placementMantel-Haenszel hazard ratiosKaplan-Meier methodVentriculoperitoneal shunt placementPostoperative epilepsyPostoperative seizuresPreoperative symptomsEpilepsy incidenceFirst seizureHazard ratioControlled TrialsEndoscopic treatmentThird ventriculostomyTreatment modalitiesSeizure riskHead circumferenceRelative riskSeizure onset
2017
Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda
Kulkarni A, Schiff S, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, MacDonald M, Cherukuri V, Warf B. Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda. New England Journal Of Medicine 2017, 377: 2456-2464. PMID: 29262276, PMCID: PMC5784827, DOI: 10.1056/nejmoa1707568.Peer-Reviewed Original ResearchConceptsETV-CPCPostinfectious hydrocephalusUgandan infantsTreatment failureCognitive outcomesBrain volumeSingle-center studyEndoscopic third ventriculostomyChoroid plexus cauterizationMajor health problemSignificant differencesLanguage scoresSecondary outcomesEndoscopic treatmentPrimary outcomeVentricular sizeThird ventriculostomyInfant hydrocephalusComputed tomographyTreatment groupsAlternative treatmentLate failureBayley ScalesBrain growthConventional treatment
2011
Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants.
Warf B, Dagi A, Kaaya B, Schiff S. Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 8: 502-8. PMID: 22044377, DOI: 10.3171/2011.8.peds11221.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusFive-year survivalShunt placementPrimary brain injuryWorse functional outcomeKaplan-Meier methodLong-term outcomesLog-rank testOutcome of treatmentEndoscopic third ventriculostomyTreatment selection biasPublic health measuresOne-thirdUgandan infantsWorst sequelaeOperative mortalityNeonatal infectionFunctional outcomeThird ventriculostomyBrain injuryPrimary treatmentCommon causeInfant hydrocephalusSurvival advantageOriginal infection