Serum complement activation in congestive heart failure
Clark D, Cleman M, Pfau S, Rollins S, Ramahi T, Mayer C, Caulin-Glaser T, Daher E, Kosiborod M, Bell L, Setaro J. Serum complement activation in congestive heart failure. American Heart Journal 2001, 141: 684-690. PMID: 11275938, DOI: 10.1067/mhj.2001.113758.Peer-Reviewed Original ResearchMeSH KeywordsAgedComplement ActivationComplement Membrane Attack ComplexFemaleHeart FailureHemodynamicsHumansMaleMiddle AgedStroke VolumeTumor Necrosis Factor-alphaConceptsCongestive heart failureSymptomatic heart failureC5b-9 levelsHeart failureClinical outcomesC5b-9Control patientsNew York Heart Association class IV symptomsComplement activationAge-matched control patientsClass IV symptomsCombined clinical outcomeAdverse clinical outcomesVentricular ejection fractionTerminal complement complex C5b-9Terminal complement activationComplement complex C5b-9Serum complement activationTerminal complement complexAdverse eventsCardiopulmonary bypassEjection fractionSerum levelsMyocardial injuryMyocardial infarction