Featured Publications
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionPrefrontal–amygdala circuits in social decision-making
Gangopadhyay P, Chawla M, Dal Monte O, Chang SWC. Prefrontal–amygdala circuits in social decision-making. Nature Neuroscience 2020, 24: 5-18. PMID: 33169032, PMCID: PMC7899743, DOI: 10.1038/s41593-020-00738-9.Peer-Reviewed Original ResearchConceptsSocial behaviorSystems neuroscience perspectivePrefrontal-amygdala pathwaysPrefrontal-amygdala circuitsPrefrontal cortical regionsSocial cognitionNeuroscience perspectiveNeural basisNeuropeptide oxytocinBrains of primatesNeural mechanismsCortical regionsNon-human primatesSpecific instantiationSocial constructMultiple levelsCognitionNeuronal activityMultiple animal speciesNeurobiologyAmygdalaBehaviorUnderpinningsPrimatesConstructsIs There a ‘Social’ Brain? Implementations and Algorithms
Lockwood PL, Apps MAJ, Chang SWC. Is There a ‘Social’ Brain? Implementations and Algorithms. Trends In Cognitive Sciences 2020, 24: 802-813. PMID: 32736965, PMCID: PMC7501252, DOI: 10.1016/j.tics.2020.06.011.Peer-Reviewed Original ResearchConceptsSocial behaviorNeural processesMotor facultiesInformation processingInfluential frameworkSocial specificitiesAlgorithmic levelGreater integrationPsychologyNeuroscienceBehaviorDifferent levelsImportant new insightsEmpirical approachMarrProcessingFundamental questionsBrainResearchMonkeysFrameworkHumansThe Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
Apps MA, Rushworth MF, Chang SW. The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others. Neuron 2016, 90: 692-707. PMID: 27196973, PMCID: PMC4885021, DOI: 10.1016/j.neuron.2016.04.018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSocial cognitionSocio-cognitive abilitiesAnterior cingulate gyrusCognitive processesError processingSocial informationCingulate cortexSocial interactionSocial behaviorCingulate gyrusCognitionTestable predictionsGyrusMotivationACCGFurther evidenceComputational propertiesKey mechanismCortexBehaviorProcessingEvidenceIndividualsAbility
2023
The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors. Neurobiology Of Learning And Memory 2023, 203: 107793. PMID: 37353191, PMCID: PMC10527225, DOI: 10.1016/j.nlm.2023.107793.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexOFC functionCognitive mapsOFC neuronsNon-social domainCore brain areasNon-social behaviorsReward-based behaviorsValues-based behaviorSocial behaviorSocial contextBrain areasBehavioral contextSocial functionComplex representationSingle subjectCortexBehaviorTremendous knowledgeIntegrated viewContextTask spaceMAP frameworkRepresentationWide array
2022
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam PT, Chang SWC. Interplay between the oxytocin and opioid systems in regulating social behaviour. Philosophical Transactions Of The Royal Society B Biological Sciences 2022, 377: 20210050. PMID: 35858101, PMCID: PMC9272147, DOI: 10.1098/rstb.2021.0050.Peer-Reviewed Original Research
2021
Levels of naturalism in social neuroscience research
Fan S, Dal Monte O, Chang SWC. Levels of naturalism in social neuroscience research. IScience 2021, 24: 102702. PMID: 34258547, PMCID: PMC8253962, DOI: 10.1016/j.isci.2021.102702.Peer-Reviewed Original ResearchSocial stimuliReal-life social interactionsSocial behaviorSocial neuroscience researchTypical social behaviorsNeural substratesEcological validityNeural responsesNeuroscience researchSocial interactionVirtual avatarCertain stimuliStimuliExperimental controlEmpirical researchSpecific processesReal-life scenariosHigh levelsResearchAvatarContingenciesSampling techniqueBehaviorNaturalismResearchers