2001
Acquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
1989
Demyelination in spinal cord injury
Waxman S. Demyelination in spinal cord injury. Journal Of The Neurological Sciences 1989, 91: 1-14. PMID: 2664092, DOI: 10.1016/0022-510x(89)90072-5.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryDemyelinated axonsFunctional recoveryCompressive spinal cord injuryAbsence of remyelinationRecovery of conductionRecovery of functionSmall-diameter axonsModification of conductionHemorrhagic necrosisPathophysiological basisClinical criteriaComplete transectionSchwann cellsDemyelinationDiameter axonsAction potentialsInjuryDemyelinated fibersAxonsRemyelinationNeurophysiological evidencePhysiological studiesTransection