2023
Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia
Benson C, King J, Kauer S, Waxman S, Tan A. Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal Of Neurophysiology 2023, 130: 1358-1366. PMID: 37877184, PMCID: PMC10972632, DOI: 10.1152/jn.00234.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionTripartite synapsesGLT-1Astrocytic GLT-1 expressionChronic neurological complicationsGLT-1 expressionAstrocyte involvementChronic spasticityUninjured shamsNeurological complicationsNeuropathic painHyperexcitability disordersH-reflexPSD-95 proteinReactive astrocytesVentral hornCord injuryMuscle toneAstrocytes' roleSpinal cordSpinal circuitsSynaptic transmissionHyperreflexiaSpasticity
2022
Dendritic Spines and Pain Memory
Benson C, King J, Reimer M, Kauer S, Waxman S, Tan A. Dendritic Spines and Pain Memory. The Neuroscientist 2022, 30: 294-314. PMID: 36461773, DOI: 10.1177/10738584221138251.Peer-Reviewed Original ResearchNeuropathic painDendritic spinesSynaptic transmissionSpinal cord dorsal hornForm of painNew therapeutic approachesSurface of neuronsDorsal hornIntractable painDeep laminaePain memoryTherapeutic approachesPainNervous systemNew therapeuticsSpineMillions of peopleInjuryDiseaseRecent studiesReview articlePrevalenceNeuronsImportant role
1990
Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus
O'Regan M, Kocsis J, Waxman S. Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus. Brain Research 1990, 527: 181-191. PMID: 1701335, DOI: 10.1016/0006-8993(90)91136-5.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineDihydropyridinesEvoked PotentialsFemaleHippocampusIn Vitro TechniquesLightMembrane PotentialsNeuronsNifedipineNimodipinePerfusionPotassiumPyramidal TractsRatsRats, Inbred StrainsSynapsesSynaptic TransmissionConceptsBay K 8644Synaptic transmissionDepressant actionIntracellular recordingsModerate membrane depolarizationMembrane depolarizationHippocampal brain slicesNormal Krebs solutionField potential responsesDepolarization-dependent increaseField potential analysisCA1 neuronsPresynaptic locusHippocampal slicesKrebs solutionPostsynaptic componentsPostsynaptic responsesPyramidal cellsNeuronal excitabilityRat hippocampusBrain slicesDirect depolarizationSpike thresholdDHP effectField potentials
1979
Electron microscopy of synapses in reptile spinal cord
Waxman S. Electron microscopy of synapses in reptile spinal cord. Neuroscience Letters 1979, 13: 237-242. PMID: 530475, DOI: 10.1016/0304-3940(79)91500-3.Peer-Reviewed Original Research