2006
Transcriptional Channelopathies of the Nervous System
Waxman S. Transcriptional Channelopathies of the Nervous System. 2006 DOI: 10.1002/9780470015902.a0006086.Peer-Reviewed Original ResearchSodium channel geneChannel genesTranscriptional channelopathiesSodium channel gene expressionChannel gene expressionGene expressionPeripheral nerve injurySpinal sensory neuronsGenesDysregulated expressionNerve injuryMultiple sclerosisSensory neuronsNervous systemCerebellar functionRecent studiesExpressionChannelopathiesAbstract Recent studiesHyperexcitabilitySclerosisInjuryNeuronsCells
2001
Transcriptional channelopathies: An emerging class of disorders
Waxman S. Transcriptional channelopathies: An emerging class of disorders. Nature Reviews Neuroscience 2001, 2: 652-659. PMID: 11533733, DOI: 10.1038/35090026.Peer-Reviewed Original ResearchConceptsNerve injuryMultiple sclerosisSodium channel geneTranscriptional channelopathiesChannel transcriptionPeripheral nerve injurySpinal sensory neuronsChannel genesExperimental nerve injuryFamily of disordersAction potential conductionAutoimmune channelopathiesDemyelinated nervesNeuropathic painDemyelinating conditionMotor abnormalitiesNeurotrophic factorClass of disordersSensory neuronsCalcium channelsChannel expressionCerebellar ataxiaPurkinje cellsPotential conductionChannelopathiesAcquired channelopathies in nerve injury and MS
Waxman S. Acquired channelopathies in nerve injury and MS. Neurology 2001, 56: 1621-1627. PMID: 11428390, DOI: 10.1212/wnl.56.12.1621.Peer-Reviewed Original ResearchConceptsNerve injurySodium channelsSensory neuron-specific sodium channelsSodium channel geneChannel genesPeripheral nerve injurySpinal sensory neuronsPathophysiology of MSSubtype-specific drugsDistinct sodium channelsVoltage-gated sodium channelsSpecific sodium channelsAxonal transectionGenetic channelopathyPrototype disorderSensory neuronsPurkinje cellsTherapeutic opportunitiesChannelopathiesAbnormal expressionInjuryMolecular changesHyperexcitabilityCellsTransection
2000
Voltage-gated sodium channels and the molecular pathogenesis of pain: a review.
Waxman SG, Cummins TR, Dib-Hajj SD, Black JA. Voltage-gated sodium channels and the molecular pathogenesis of pain: a review. The Journal Of Rehabilitation Research And Development 2000, 37: 517-28. PMID: 11322150.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsDRG neuronsNervous systemSodium channelsDistinct voltage-gated sodium channelsAction potentialsSpinal sensory neuronsSodium channel expressionSpontaneous action potentialsDifferent sodium channelsSpecific sodium channelsUnderstanding of painHigh-frequency activityInflammatory painPain pathwaysChronic painNociceptive signalsPeripheral nervesSensory neuronsNew therapiesPainChannel expressionMolecular pathogenesisPharmacologic manipulationNeuron cell membrane
1997
NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons
Black J, Langworthy K, Hinson A, Dib-Hajj S, Waxman S. NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons. Neuroreport 1997, 8: 2331-2335. PMID: 9243635, DOI: 10.1097/00001756-199707070-00046.Peer-Reviewed Original ResearchConceptsNeurotrophin nerve growth factorSmall DRG neuronsExogenous NGFDRG neuronsDifferent sodium channel genesSmall dorsal root ganglion neuronsDorsal root ganglion neuronsSciatic nerve transectionMRNA levelsSpinal sensory neuronsNerve growth factorNerve transectionDRG culturesGanglion neuronsAlpha-IIIAdult ratsSensory neuronsPeripheral targetsSodium channel transcriptsMRNA expressionMembrane excitabilityNeuronsGrowth factorRetrograde transportChannel transcripts
1996
Expression of mRNA for a sodium channel in subfamily 2 in spinal sensory neurons
Waxman S, Black J. Expression of mRNA for a sodium channel in subfamily 2 in spinal sensory neurons. Neurochemical Research 1996, 21: 395-401. PMID: 8734431, DOI: 10.1007/bf02527702.Peer-Reviewed Original ResearchConceptsDorsal root gangliaSpinal sensory neuronsSchwann cellsDRG neuronsSensory neuronsRat dorsal root gangliaSodium channelsΒ1 subunitExpression of mRNARoot gangliaSpinal cordSitu hybridization cytochemistryNeuronsΑ-subunitAntisense riboprobesBlot analysisType IMRNACellsExpressionHigh levelsGangliaRNA blot analysisHippocampusCord
1995
Na+ channel β1 subunit mRNA: differential expression in rat spinal sensory neurons
Oh Y, Sashihara S, Black J, Waxman S. Na+ channel β1 subunit mRNA: differential expression in rat spinal sensory neurons. Brain Research 1995, 30: 357-361. PMID: 7637585, DOI: 10.1016/0169-328x(95)00052-t.Peer-Reviewed Original ResearchConceptsDRG neuronsNervous systemChannel beta 1 subunit (Na beta 1) mRNARat dorsal root ganglion neuronsCell bodiesDorsal root ganglion neuronsSubunit mRNAsBeta 1 mRNA expressionRat central nervous systemSmall DRG neuronsLarge DRG neuronsSpinal sensory neuronsPeripheral nervous systemPostnatal day 4Central nervous systemBeta 1 mRNABeta 1 subunit mRNASitu hybridization histochemistryAdult DRGGanglion neuronsSensory neuronsDay 4Hybridization histochemistryMRNA expressionNeurons