1990
Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus
O'Regan M, Kocsis J, Waxman S. Depolarization-dependent actions of dihydropyridines on synaptic transmission in the in vitro rat hippocampus. Brain Research 1990, 527: 181-191. PMID: 1701335, DOI: 10.1016/0006-8993(90)91136-5.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineDihydropyridinesEvoked PotentialsFemaleHippocampusIn Vitro TechniquesLightMembrane PotentialsNeuronsNifedipineNimodipinePerfusionPotassiumPyramidal TractsRatsRats, Inbred StrainsSynapsesSynaptic TransmissionConceptsBay K 8644Synaptic transmissionDepressant actionIntracellular recordingsModerate membrane depolarizationMembrane depolarizationHippocampal brain slicesNormal Krebs solutionField potential responsesDepolarization-dependent increaseField potential analysisCA1 neuronsPresynaptic locusHippocampal slicesKrebs solutionPostsynaptic componentsPostsynaptic responsesPyramidal cellsNeuronal excitabilityRat hippocampusBrain slicesDirect depolarizationSpike thresholdDHP effectField potentials
1987
Changes in synaptic morphology associated with presynaptic and postsynaptic activity: An in vitro study of the electrosensory organ of the thornback ray
Fields R, Ellisman M, Waxman S. Changes in synaptic morphology associated with presynaptic and postsynaptic activity: An in vitro study of the electrosensory organ of the thornback ray. Synapse 1987, 1: 335-346. PMID: 2901790, DOI: 10.1002/syn.890010407.Peer-Reviewed Original ResearchConceptsPostsynaptic membraneNeurotransmitter glutamateSynaptic morphologyUltrastructure of synapsesPresynaptic membraneRibbon synapsesDirect depolarizationSynaptic activityPostsynaptic activitySpontaneous activitySynaptic fatigueSynaptic efficacyMorphological changesSynaptic structureSynapsesCytoskeletal alterations