Sodium Channels and Pain
Cummins T, Waxman S, Wood J. Sodium Channels and Pain. 2019, 233-262. DOI: 10.1093/oxfordhb/9780190860509.013.3.Peer-Reviewed Original ResearchSodium channel blockersPain conditionsChannel blockersSodium channelsAnalgesic drug targetsDifferent pain statesFunction Nav1.7 mutationsMost pain conditionsPeripheral sodium channelsSodium channel subtypesDamage-sensing neuronsDrug developmentVoltage-gated sodium channelsSodium channel isoformsDrug development programsIon channelsExcellent analgesicPain controlPain reliefPain statesNav1.7 mutationSodium-selective ion channelsNew analgesicsLocal anestheticsTherapeutic approaches