2012
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM. Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nature Neuroscience 2012, 15: 1227-1235. PMID: 22820466, PMCID: PMC3431439, DOI: 10.1038/nn.3178.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBlotting, WesternCalcium SignalingCell LineDendritic SpinesElectroencephalographyEnzyme ActivationHumansMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeuronsPhosphorylationProtein BindingProto-Oncogene Proteins c-fynPrPC ProteinsRatsReceptors, N-Methyl-D-AspartateSeizuresSynapses
2010
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model
Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer’s disease mouse model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 19014-19019. PMID: 20956308, PMCID: PMC2973892, DOI: 10.1073/pnas.1013543107.Peer-Reviewed Original ResearchConceptsStriatal-enriched tyrosine phosphataseTyrosine phosphataseDisease mouse modelStriatal-enriched phosphataseAlzheimer's diseaseCellular deficitsGenetic manipulationNMDA receptorsMouse modelTriple transgenic AD mouse modelIncurable neurodegenerative disorderTransgenic AD mouse modelAlzheimer's disease mouse modelPathophysiology of ADSTEP inhibitorGenetic reductionAD mouse modelHuman AD patientsSoluble Aβ oligomersSynaptic functionPhosphataseNeurodegenerative disordersAD patientsDevastating disorderAnimal models
1999
Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro
Fryer HJ, Knox RJ, Strittmatter SM, Kalb RG. Excitotoxic Death of a Subset of Embryonic Rat Motor Neurons In Vitro. Journal Of Neurochemistry 1999, 72: 500-513. PMID: 9930721, DOI: 10.1046/j.1471-4159.1999.0720500.x.Peer-Reviewed Original ResearchMeSH Keywords6-Cyano-7-nitroquinoxaline-2,3-dioneAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalciumCalcium ChannelsCalcium Channels, L-TypeCell Culture TechniquesCell DeathCells, CulturedDizocilpine MaleateDose-Response Relationship, DrugExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFemaleGlutamic AcidGlutamineGlycineKainic AcidMembrane PotentialsMotor NeuronsN-MethylaspartateNerve Tissue ProteinsNeurotoxinsPotassiumPregnancyRatsRats, Sprague-DawleyReceptors, AMPAReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSpinal CordConceptsGlutamate receptor agonistsMotor neuronsReceptor agonistNon-NMDA glutamate receptor agonistsIntracellular Ca2Agonist-evoked intracellular Ca2Specific glutamate receptor agonistsIonotropic glutamate receptor activationReceptor subtype-specific antagonistsSpinal cord motor neuronsSubtype-specific antagonistsCultured motor neuronsGlutamate receptor expressionRat motor neuronsMost motor neuronsGlutamate receptor activationL-type Ca2Subunit-specific antibodiesTime-dependent mannerReceptor phenotypeChannel antagonistsReceptor expressionNeurotoxic effectsRoute of entryExtracellular Ca2Isolation of Receptor Clones by Expression Screening in Xenopus Oocytes
Nakamura F, Goshima Y, Strittmatter S, Kawamoto S. Isolation of Receptor Clones by Expression Screening in Xenopus Oocytes. Methods In Molecular Biology 1999, 128: 1-18. PMID: 10320969, DOI: 10.1385/1-59259-683-5:1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCloning, MolecularGene ExpressionOocytesReceptors, N-Methyl-D-AspartateXenopus laevis
1998
The Role of Nitric Oxide and NMDA Receptors in the Development of Motor Neuron Dendrites
Inglis F, Furia F, Zuckerman K, Strittmatter S, Kalb R. The Role of Nitric Oxide and NMDA Receptors in the Development of Motor Neuron Dendrites. Journal Of Neuroscience 1998, 18: 10493-10501. PMID: 9852587, PMCID: PMC6793344, DOI: 10.1523/jneurosci.18-24-10493.1998.Peer-Reviewed Original ResearchConceptsNeuronal nitric oxide synthaseMotor neuronsWild-type animalsNitric oxideSpinal cordNMDA receptorsDendritic bifurcationsContribution of NOPrecise synaptic connectivityMotor neuron poolDrug treatment groupNMDA receptor blockNitric oxide synthasePostnatal day 7Wild-type miceImmunohistochemical examinationMK-801Oxide synthaseNeuron poolsReceptor blockSholl analysisTreatment groupsSynaptic connectivityLong dendritesDay 7