2011
Differential but Competitive Binding of Nogo Protein and Class I Major Histocompatibility Complex (MHCI) to the PIR-B Ectodomain Provides an Inhibition of Cells*
Matsushita H, Endo S, Kobayashi E, Sakamoto Y, Kobayashi K, Kitaguchi K, Kuroki K, Söderhäll A, Maenaka K, Nakamura A, Strittmatter SM, Takai T. Differential but Competitive Binding of Nogo Protein and Class I Major Histocompatibility Complex (MHCI) to the PIR-B Ectodomain Provides an Inhibition of Cells*. Journal Of Biological Chemistry 2011, 286: 25739-25747. PMID: 21636572, PMCID: PMC3138294, DOI: 10.1074/jbc.m110.157859.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta 2-MicroglobulinBinding, CompetitiveFemaleHistocompatibility Antigens Class IHLA AntigensHLA-G AntigensHumansImmunologic FactorsInterleukin-6LipopolysaccharidesMast CellsMiceMice, Inbred C57BLMyelin ProteinsMyelin-Associated GlycoproteinNeurotransmitter AgentsNogo ProteinsProtein Structure, TertiaryRatsReceptors, ImmunologicSubstrate SpecificityConceptsMajor histocompatibility complexRecent unexpected findingsClass I major histocompatibility complexI major histocompatibility complexInterleukin-6 releaseClass I MHC moleculesC-terminal ectodomainNovel inhibitory roleCultured mast cellsI MHC moleculesTerminal domainPeripheral toleranceInhibitory receptorsInhibition of cellMast cellsOutgrowth inhibitorB cellsMyeloid cellsImmune systemMHC moleculesNeurite regenerationNovel mechanismNogo proteinEctodomainInhibitory role
2008
Release of MICAL Autoinhibition by Semaphorin-Plexin Signaling Promotes Interaction with Collapsin Response Mediator Protein
Schmidt EF, Shim SO, Strittmatter SM. Release of MICAL Autoinhibition by Semaphorin-Plexin Signaling Promotes Interaction with Collapsin Response Mediator Protein. Journal Of Neuroscience 2008, 28: 2287-2297. PMID: 18305261, PMCID: PMC2846290, DOI: 10.1523/jneurosci.5646-07.2008.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell Adhesion MoleculesCell Line, TransformedChick EmbryoCytoskeletal ProteinsFlavin-Adenine DinucleotideGanglia, SpinalGenetic VectorsHIVHumansImmunoprecipitationIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMembrane GlycoproteinsMicrofilament ProteinsMixed Function OxygenasesMutationNerve Tissue ProteinsNeuritesNeuronsPeptide FragmentsProtein BindingSemaphorin-3ASemaphorinsSignal TransductionTransfectionConceptsCollapsin response mediator proteinsMediator proteinsCytoplasmic proteinsEnzymatic domainsCatalytic domainPlexin functionPlexin receptorsTerminal domainMICALPromotes interactionAxon guidanceNeuronal developmentAxonal guidanceEnzymatic activityProteinAutoinhibitionDomainPlexinsSignalingSemaphorinsActivatorAssociatesInteractionActivityActivation