2011
Cartilage Acidic Protein–1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation
Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K. Cartilage Acidic Protein–1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation. Science 2011, 333: 769-773. PMID: 21817055, PMCID: PMC3244695, DOI: 10.1126/science.1204144.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBinding SitesCalcium-Binding ProteinsCell LineCells, CulturedGPI-Linked ProteinsGrowth ConesHumansImmunohistochemistryLigandsMiceMice, Inbred ICRMyelin ProteinsNogo ProteinsNogo Receptor 1Olfactory PathwaysProsencephalonProtein BindingReceptors, Cell SurfaceSignal TransductionConceptsTract formationNogo receptor 1Axon growth inhibitorsProtein 1BEndogenous antagonismAxon tract formationReceptor antagonistGrowth cone collapseAxonal projectionsCircuitry formationNeural circuitry formationMouse brainReceptor 1LOT formationNeural regenerationNgR1Key moleculesCone collapseMiceFluorophore-assisted light inactivationGrowth inhibitorAntagonistBrainMyelinNogoMyelin associated inhibitors: A link between injury-induced and experience-dependent plasticity
Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: A link between injury-induced and experience-dependent plasticity. Experimental Neurology 2011, 235: 43-52. PMID: 21699896, PMCID: PMC3189418, DOI: 10.1016/j.expneurol.2011.06.006.Peer-Reviewed Original ResearchConceptsExperience-dependent plasticityAnatomical rearrangementsNogo-66 receptor 1Spinal cord injuryNeurologic recoveryFunctional recoveryInciting stimulusCNS injuryCord injuryAxonal regenerationAdult CNSInjury studiesAnimal modelsReceptor 1Common receptorPaired-ImmunoglobulinMyelinInhibitorsInjuryAnatomical growthCNSReceptorsWide spectrumExtracellular matrixGrowth inhibitor
2003
Nogo-C is sufficient to delay nerve regeneration
Kim J, Bonilla IE, Qiu D, Strittmatter SM. Nogo-C is sufficient to delay nerve regeneration. Molecular And Cellular Neuroscience 2003, 23: 451-459. PMID: 12837628, DOI: 10.1016/s1044-7431(03)00076-9.Peer-Reviewed Original ResearchConceptsAxonal regenerationTransgenic miceSciatic nerve injurySciatic nerve crushAxon growth inhibitorsWild-type miceCentral nervous systemC transgenic miceDecreased recovery ratePeripheral Schwann cellsNerve injuryNerve crushMotor functionPeripheral clearanceSchwann cellsCNS expressionNerve regenerationNervous systemAdult mammalsMiceNogoCellsGrowth inhibitorExpressionInjuryAxon Regeneration in Young Adult Mice Lacking Nogo-A/B
Kim J, Li S, GrandPré T, Qiu D, Strittmatter SM. Axon Regeneration in Young Adult Mice Lacking Nogo-A/B. Neuron 2003, 38: 187-199. PMID: 12718854, DOI: 10.1016/s0896-6273(03)00147-8.Peer-Reviewed Original ResearchConceptsCNS axon repairAxon growth inhibitorsSpinal cord injuryAdult mammalian brainAxonal sproutingCorticospinal axonsCord segmentsCord injuryTract tracingAdult CNSLocomotor functionMice LackingAxon repairMammalian brainB expressionMiceYoung adultsInjuryNumerous fibersNormal locomotionAxonsNogoTransectionGrowth inhibitorLittle regeneration
1995
Neuronal Guidance Molecules: Inhibitory and Soluble Factors
Strittmatter S. Neuronal Guidance Molecules: Inhibitory and Soluble Factors. The Neuroscientist 1995, 1: 255-258. DOI: 10.1177/107385849500100502.Peer-Reviewed Original ResearchCell-surface adhesive proteinsMatrix-bound factorsGuidance moleculesImportance of moleculesAxonal guidance factorsAxonal growth conesExtracellular matrix componentsNeural developmentSoluble factorsPhysiological roleSemaphorin familyMolecular levelNeuronal guidance moleculesAdhesive proteinsGrowth conesGuidance factorsMatrix componentsGrowth inhibitorCentral roleAxonal outgrowthCNS myelinAxonal growth inhibitorsAxonal guidance moleculesRegenerationMolecules