2009
Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation
Ellenberg D, Shi J, Jain S, Chang JH, Ripps H, Brady S, Melhem ER, Lakkis F, Adamis A, Chen DF, Ellis-Behnke R, Langer RS, Strittmatter SM, Azar DT. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. British Journal Of Ophthalmology 2009, 93: 1134. PMID: 19286686, PMCID: PMC2850278, DOI: 10.1136/bjo.2008.155267.Peer-Reviewed Original ResearchConceptsOptic nerve transectionWhole-eye transplantationRGC survivalVisual functionRetinal ganglion cell survivalOuter retina functionGanglion cell survivalOuter retinal functionEye transplantationRetinal functionDonor eyesRetina functionTransectionTransplantationEnucleationSurvivalCell survivalCurrent literatureFuture studiesReviewCold-blooded vertebratesReperfusionNeurotrophinsSpecific questions
2007
ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases
Schmandke A, Schmandke A, Strittmatter SM. ROCK and Rho: Biochemistry and Neuronal Functions of Rho-Associated Protein Kinases. The Neuroscientist 2007, 13: 454-469. PMID: 17901255, PMCID: PMC2849133, DOI: 10.1177/1073858407303611.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCentral Nervous SystemCytoskeletonHumansLipoproteinsMyelin ProteinsNerve Tissue ProteinsNeuronsNogo ProteinsProtein Processing, Post-TranslationalReceptor Protein-Tyrosine KinasesReceptors, G-Protein-CoupledReceptors, ImmunologicRho GTP-Binding ProteinsRho-Associated KinasesSignal TransductionConceptsProtein kinaseRho-Associated Protein KinaseSignal transduction mechanismsNeuronal functionDiverse neuronal functionsActin cytoskeletonRho familyExtracellular signalsROCK functionSignaling pathwaysBiochemical knowledgeCell survivalTransduction mechanismsCell migrationAxonal guidanceDendritic spine morphologyKinaseROCK pathwayPathwayNeuronal regenerationSpine morphologyRhoBrain developmentKey rolePotential sites
1999
Go protein-dependent survival of primary accessory olfactory neurons
Tanaka M, Treloar H, Kalb R, Greer C, Strittmatter S. Go protein-dependent survival of primary accessory olfactory neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 14106-14111. PMID: 10570206, PMCID: PMC24198, DOI: 10.1073/pnas.96.24.14106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell Adhesion Molecules, NeuronalCell SurvivalCells, CulturedFemaleGTP-Binding Protein alpha Subunit, Gi2GTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gi-GoHeterotrimeric GTP-Binding ProteinsHumansMaleMiceMice, Inbred C57BLMice, KnockoutNeural Cell Adhesion MoleculesNeuronsProto-Oncogene ProteinsProto-Oncogene Proteins c-fosRatsSynaptophysinVomeronasal OrganConceptsPosterior accessory olfactory bulbCell survivalAccessory olfactory bulbG proteinsOlfactory systemAccessory olfactory systemG protein-independent processReceptor-coupled G proteinsG protein-coupled receptor familyProtein-coupled receptor familyVNO neuronsAxonal targetingSensory functionAxonal guidanceReceptor familyAnterior accessory olfactory bulbTargeted deletionOlfactory neuronsReceptor neuronsC-Fos immunoreactivityProteinApoptotic neuronsNeurons decreasesOlfactory bulbSensory activation