2019
Genomics Analysis of L-DOPA Exposure in Drosophila sechellia
Lanno S, Lam I, Drum Z, Linde S, Gregory S, Shimshak S, Becker M, Brew K, Budhiraja A, Carter E, Chigweshe L, Collins K, Earley T, Einstein H, Fan A, Goss S, Hagen E, Hutcheon S, Kim T, Mitchell M, Neri N, Patterson S, Ransom G, Sanchez G, Wiener B, Zhao D, Coolon J. Genomics Analysis of L-DOPA Exposure in Drosophila sechellia. G3: Genes, Genomes, Genetics 2019, 9: 3973-3980. PMID: 31575638, PMCID: PMC6893205, DOI: 10.1534/g3.119.400552.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaprylatesDietDrosophilaGene Expression RegulationGene OntologyGenome, InsectGenomicsLevodopaSpecies SpecificityConceptsToxin-resistant phenotypeHost specializationResistance phenotypeGene expression responsesDrosophila sechelliaSpecies pairsGenomic analysisGenomic studiesFunctional geneticsReproductive successEcological adaptationGenomic techniquesToxic fruitsGenetic basisExpression responsesKnock-downHeterologous speciesToxin resistanceGenesFruit flyL-DOPA exposureGenomeSpeciesSupplementation of dietsPhenotype
2017
Transcriptomic Analysis of Octanoic Acid Response in Drosophila sechellia Using RNA-Sequencing
Lanno S, Gregory S, Shimshak S, Alverson M, Chiu K, Feil A, Findley M, Forman T, Gordon J, Ho J, Krupp J, Lam I, Lane J, Linde S, Morse A, Rusk S, Ryan R, Saniee A, Sheth R, Siranosian J, Sirichantaropart L, Sternlieb S, Zaccardi C, Coolon J. Transcriptomic Analysis of Octanoic Acid Response in Drosophila sechellia Using RNA-Sequencing. G3: Genes, Genomes, Genetics 2017, 7: 3867-3873. PMID: 29021218, PMCID: PMC5714484, DOI: 10.1534/g3.117.300297.Peer-Reviewed Original ResearchConceptsQuantitative trait lociOA resistanceGene expression analysisGene OntologyResistance genesRNA sequencingRNA interferenceExpression analysisConsistent with previous functional studiesFunctional studiesGene family membersAnnotated orthologsDrosophila sechelliaEffect lociRNA-seqLevels of octanoic acidTrait lociCuticle developmentDefense responsesExpressed genesToxic fruitsTranscriptome analysisDownregulated genesUpregulated genesGenes