2022
Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet
Drum Z, Lanno S, Gregory S, Shimshak S, Barr W, Gatesman A, Schadt M, Sanford J, Arkin A, Assignon B, Colorado S, Dalgarno C, Devanny T, Ghandour T, Griffin R, Hogan M, Horowitz E, McGhie E, Multer J, O'Halloran H, Ofori-Darko K, Pokushalov D, Richards N, Sagarin K, Taylor N, Thielking A, Towle P, Coolon J. Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet. G3: Genes, Genomes, Genetics 2022, 12: jkac153. PMID: 35736356, PMCID: PMC9526069, DOI: 10.1093/g3journal/jkac153.Peer-Reviewed Original ResearchConceptsGene expression responsesD. sechelliaGenome-wide gene expression responsesExpression responsesTranscription factor prediction analysesNoni fruitDrosophila sechelliaGenomic analysisRegulatory networksIdentified genesHost specialistsToxic fruitsGenetic mechanismsRNA sequencingBiochemical pathwaysToxin resistanceFruit flyFruit dietGenesFruitMorinda citrifoliaAbundant compoundsGeneral responseNoniRegulation
2021
Genomics analysis of hexanoic acid exposure in Drosophila species
Drum Z, Lanno S, Gregory S, Shimshak S, Ahamed M, Barr W, Bekele B, Biester A, Castro C, Connolly L, DelGaudio N, Humphrey W, Karimi H, Karolczak S, Lawrence T, McCracken A, Miller-Medzon N, Murphy L, Park C, Park S, Qiu C, Serra K, Snyder G, Strauss A, Tang S, Vyzas C, Coolon J. Genomics analysis of hexanoic acid exposure in Drosophila species. G3: Genes, Genomes, Genetics 2021, 12: jkab354. PMID: 34718544, PMCID: PMC8727985, DOI: 10.1093/g3journal/jkab354.Peer-Reviewed Original ResearchConceptsD. sechelliaDrosophila sechelliaSets of differentially expressed genesSpecialist D. sechelliaFruit of Morinda citrifoliaDifferentially expressed genesAcid resistanceHexanoic acidM. citrifolia fruitDrosophila speciesD. melanogasterGeneralist speciesGenomic analysisFruit of M. citrifoliaCandidate genesDietary specialistsDietary specializationTranscriptional responseEcological communitiesTrophic interactionsHost plantsGenetic basisRNA sequencingDownregulated genesGene expression
2019
Genomics Analysis of L-DOPA Exposure in Drosophila sechellia
Lanno S, Lam I, Drum Z, Linde S, Gregory S, Shimshak S, Becker M, Brew K, Budhiraja A, Carter E, Chigweshe L, Collins K, Earley T, Einstein H, Fan A, Goss S, Hagen E, Hutcheon S, Kim T, Mitchell M, Neri N, Patterson S, Ransom G, Sanchez G, Wiener B, Zhao D, Coolon J. Genomics Analysis of L-DOPA Exposure in Drosophila sechellia. G3: Genes, Genomes, Genetics 2019, 9: 3973-3980. PMID: 31575638, PMCID: PMC6893205, DOI: 10.1534/g3.119.400552.Peer-Reviewed Original ResearchConceptsToxin-resistant phenotypeHost specializationResistance phenotypeGene expression responsesDrosophila sechelliaSpecies pairsGenomic analysisGenomic studiesFunctional geneticsReproductive successEcological adaptationGenomic techniquesToxic fruitsGenetic basisExpression responsesKnock-downHeterologous speciesToxin resistanceGenesFruit flyL-DOPA exposureGenomeSpeciesSupplementation of dietsPhenotype