2022
Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet
Drum Z, Lanno S, Gregory S, Shimshak S, Barr W, Gatesman A, Schadt M, Sanford J, Arkin A, Assignon B, Colorado S, Dalgarno C, Devanny T, Ghandour T, Griffin R, Hogan M, Horowitz E, McGhie E, Multer J, O'Halloran H, Ofori-Darko K, Pokushalov D, Richards N, Sagarin K, Taylor N, Thielking A, Towle P, Coolon J. Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet. G3: Genes, Genomes, Genetics 2022, 12: jkac153. PMID: 35736356, PMCID: PMC9526069, DOI: 10.1093/g3journal/jkac153.Peer-Reviewed Original ResearchConceptsGene expression responsesD. sechelliaGenome-wide gene expression responsesExpression responsesTranscription factor prediction analysesNoni fruitDrosophila sechelliaGenomic analysisRegulatory networksIdentified genesHost specialistsToxic fruitsGenetic mechanismsRNA sequencingBiochemical pathwaysToxin resistanceFruit flyFruit dietGenesFruitMorinda citrifoliaAbundant compoundsGeneral responseNoniRegulation
2019
Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance
Lanno S, Coolon J. Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance. Insect Molecular Biology 2019, 28: 798-806. PMID: 30977928, DOI: 10.1111/imb.12587.Peer-Reviewed Original ResearchConceptsDetoxification gene familiesD. sechelliaGene familyOA resistanceGenomic regionsToxin resistanceMajor-effect lociMedium-chain fatty acids octanoic acidSynergists diethyl maleateDrosophila sechelliaChromosome 3RDefence compoundsEffect lociSechelliaOctanoic acidHost plantsGenetic basisCytochrome P450 enzymatic activityEnzymatic activityMorinda citrifoliaHexanoic acidAcid resistanceGlutathione-S-transferaseEsterase activityToxin