Genomics Analysis of L-DOPA Exposure in Drosophila sechellia
Lanno S, Lam I, Drum Z, Linde S, Gregory S, Shimshak S, Becker M, Brew K, Budhiraja A, Carter E, Chigweshe L, Collins K, Earley T, Einstein H, Fan A, Goss S, Hagen E, Hutcheon S, Kim T, Mitchell M, Neri N, Patterson S, Ransom G, Sanchez G, Wiener B, Zhao D, Coolon J. Genomics Analysis of L-DOPA Exposure in Drosophila sechellia. G3: Genes, Genomes, Genetics 2019, 9: 3973-3980. PMID: 31575638, PMCID: PMC6893205, DOI: 10.1534/g3.119.400552.Peer-Reviewed Original ResearchConceptsToxin-resistant phenotypeHost specializationResistance phenotypeGene expression responsesDrosophila sechelliaSpecies pairsGenomic analysisGenomic studiesFunctional geneticsReproductive successEcological adaptationGenomic techniquesToxic fruitsGenetic basisExpression responsesKnock-downHeterologous speciesToxin resistanceGenesFruit flyL-DOPA exposureGenomeSpeciesSupplementation of dietsPhenotypeInvestigating the role of Osiris genes in Drosophila sechellia larval resistance to a host plant toxin
Lanno S, Shimshak S, Peyser R, Linde S, Coolon J. Investigating the role of Osiris genes in Drosophila sechellia larval resistance to a host plant toxin. Ecology And Evolution 2019, 9: 1922-1933. PMID: 30847082, PMCID: PMC6392368, DOI: 10.1002/ece3.4885.Peer-Reviewed Original ResearchOA resistanceAdaptive phenotypic changesResistant to OAGenomic regionsGenetic basisGenome-wide differential gene expressionPhenotypic changesToxic host plantsFine-mapping QTLDifferential gene expressionHost plant toxinsMultiple life stagesOsiris genesLife stagesGenetic mapHost specializationFamily genesHost plantsResistance genesRNA sequencingRNA interferenceExposure to OAGene expressionGenesFruit fly