2019
Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance
Lanno S, Coolon J. Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance. Insect Molecular Biology 2019, 28: 798-806. PMID: 30977928, DOI: 10.1111/imb.12587.Peer-Reviewed Original ResearchConceptsDetoxification gene familiesD. sechelliaGene familyOA resistanceGenomic regionsToxin resistanceMajor-effect lociMedium-chain fatty acids octanoic acidSynergists diethyl maleateDrosophila sechelliaChromosome 3RDefence compoundsEffect lociSechelliaOctanoic acidHost plantsGenetic basisCytochrome P450 enzymatic activityEnzymatic activityMorinda citrifoliaHexanoic acidAcid resistanceGlutathione-S-transferaseEsterase activityToxinInvestigating the role of Osiris genes in Drosophila sechellia larval resistance to a host plant toxin
Lanno S, Shimshak S, Peyser R, Linde S, Coolon J. Investigating the role of Osiris genes in Drosophila sechellia larval resistance to a host plant toxin. Ecology And Evolution 2019, 9: 1922-1933. PMID: 30847082, PMCID: PMC6392368, DOI: 10.1002/ece3.4885.Peer-Reviewed Original ResearchOA resistanceAdaptive phenotypic changesResistant to OAGenomic regionsGenetic basisGenome-wide differential gene expressionPhenotypic changesToxic host plantsFine-mapping QTLDifferential gene expressionHost plant toxinsMultiple life stagesOsiris genesLife stagesGenetic mapHost specializationFamily genesHost plantsResistance genesRNA sequencingRNA interferenceExposure to OAGene expressionGenesFruit fly
2017
Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine‐mapped region
López J, Lanno S, Auerbach J, Moskowitz E, Sligar L, Wittkopp P, Coolon J. Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine‐mapped region. Molecular Ecology 2017, 26: 1148-1160. PMID: 28035709, PMCID: PMC5330365, DOI: 10.1111/mec.14001.Peer-Reviewed Original ResearchConceptsD. sechelliaOA resistanceDrosophila sechelliaRNA interferenceGenetic basisEvolutionary changesTissue-specific RNA interferenceFine-mapped regionKnock down expressionGene expression analysisD. simulansSister speciesChromosome 3RGenomic regionsD. melanogasterDefence compoundsLevel of expressionToxic fruitsFat bodySpecies of fruit fliesEnvironmental plasticityGenesSeychelles IslandsFruit flyFunctional analysis