2019
Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance
Lanno S, Coolon J. Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance. Insect Molecular Biology 2019, 28: 798-806. PMID: 30977928, DOI: 10.1111/imb.12587.Peer-Reviewed Original ResearchConceptsDetoxification gene familiesD. sechelliaGene familyOA resistanceGenomic regionsToxin resistanceMajor-effect lociMedium-chain fatty acids octanoic acidSynergists diethyl maleateDrosophila sechelliaChromosome 3RDefence compoundsEffect lociSechelliaOctanoic acidHost plantsGenetic basisCytochrome P450 enzymatic activityEnzymatic activityMorinda citrifoliaHexanoic acidAcid resistanceGlutathione-S-transferaseEsterase activityToxin
2017
Transcriptomic Analysis of Octanoic Acid Response in Drosophila sechellia Using RNA-Sequencing
Lanno S, Gregory S, Shimshak S, Alverson M, Chiu K, Feil A, Findley M, Forman T, Gordon J, Ho J, Krupp J, Lam I, Lane J, Linde S, Morse A, Rusk S, Ryan R, Saniee A, Sheth R, Siranosian J, Sirichantaropart L, Sternlieb S, Zaccardi C, Coolon J. Transcriptomic Analysis of Octanoic Acid Response in Drosophila sechellia Using RNA-Sequencing. G3: Genes, Genomes, Genetics 2017, 7: 3867-3873. PMID: 29021218, PMCID: PMC5714484, DOI: 10.1534/g3.117.300297.Peer-Reviewed Original ResearchConceptsQuantitative trait lociOA resistanceGene expression analysisGene OntologyResistance genesRNA sequencingRNA interferenceExpression analysisConsistent with previous functional studiesFunctional studiesGene family membersAnnotated orthologsDrosophila sechelliaEffect lociRNA-seqLevels of octanoic acidTrait lociCuticle developmentDefense responsesExpressed genesToxic fruitsTranscriptome analysisDownregulated genesUpregulated genesGenes