2021
Genomics analysis of hexanoic acid exposure in Drosophila species
Drum Z, Lanno S, Gregory S, Shimshak S, Ahamed M, Barr W, Bekele B, Biester A, Castro C, Connolly L, DelGaudio N, Humphrey W, Karimi H, Karolczak S, Lawrence T, McCracken A, Miller-Medzon N, Murphy L, Park C, Park S, Qiu C, Serra K, Snyder G, Strauss A, Tang S, Vyzas C, Coolon J. Genomics analysis of hexanoic acid exposure in Drosophila species. G3: Genes, Genomes, Genetics 2021, 12: jkab354. PMID: 34718544, PMCID: PMC8727985, DOI: 10.1093/g3journal/jkab354.Peer-Reviewed Original ResearchConceptsD. sechelliaDrosophila sechelliaSets of differentially expressed genesSpecialist D. sechelliaFruit of Morinda citrifoliaDifferentially expressed genesAcid resistanceHexanoic acidM. citrifolia fruitDrosophila speciesD. melanogasterGeneralist speciesGenomic analysisFruit of M. citrifoliaCandidate genesDietary specialistsDietary specializationTranscriptional responseEcological communitiesTrophic interactionsHost plantsGenetic basisRNA sequencingDownregulated genesGene expression
2017
Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine‐mapped region
López J, Lanno S, Auerbach J, Moskowitz E, Sligar L, Wittkopp P, Coolon J. Genetic basis of octanoic acid resistance in Drosophila sechellia: functional analysis of a fine‐mapped region. Molecular Ecology 2017, 26: 1148-1160. PMID: 28035709, PMCID: PMC5330365, DOI: 10.1111/mec.14001.Peer-Reviewed Original ResearchConceptsD. sechelliaOA resistanceDrosophila sechelliaRNA interferenceGenetic basisEvolutionary changesTissue-specific RNA interferenceFine-mapped regionKnock down expressionGene expression analysisD. simulansSister speciesChromosome 3RGenomic regionsD. melanogasterDefence compoundsLevel of expressionToxic fruitsFat bodySpecies of fruit fliesEnvironmental plasticityGenesSeychelles IslandsFruit flyFunctional analysis