2021
Genomics analysis of hexanoic acid exposure in Drosophila species
Drum Z, Lanno S, Gregory S, Shimshak S, Ahamed M, Barr W, Bekele B, Biester A, Castro C, Connolly L, DelGaudio N, Humphrey W, Karimi H, Karolczak S, Lawrence T, McCracken A, Miller-Medzon N, Murphy L, Park C, Park S, Qiu C, Serra K, Snyder G, Strauss A, Tang S, Vyzas C, Coolon J. Genomics analysis of hexanoic acid exposure in Drosophila species. G3: Genes, Genomes, Genetics 2021, 12: jkab354. PMID: 34718544, PMCID: PMC8727985, DOI: 10.1093/g3journal/jkab354.Peer-Reviewed Original ResearchConceptsD. sechelliaDrosophila sechelliaSets of differentially expressed genesSpecialist D. sechelliaFruit of Morinda citrifoliaDifferentially expressed genesAcid resistanceHexanoic acidM. citrifolia fruitDrosophila speciesD. melanogasterGeneralist speciesGenomic analysisFruit of M. citrifoliaCandidate genesDietary specialistsDietary specializationTranscriptional responseEcological communitiesTrophic interactionsHost plantsGenetic basisRNA sequencingDownregulated genesGene expression
2019
Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance
Lanno S, Coolon J. Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance. Insect Molecular Biology 2019, 28: 798-806. PMID: 30977928, DOI: 10.1111/imb.12587.Peer-Reviewed Original ResearchConceptsDetoxification gene familiesD. sechelliaGene familyOA resistanceGenomic regionsToxin resistanceMajor-effect lociMedium-chain fatty acids octanoic acidSynergists diethyl maleateDrosophila sechelliaChromosome 3RDefence compoundsEffect lociSechelliaOctanoic acidHost plantsGenetic basisCytochrome P450 enzymatic activityEnzymatic activityMorinda citrifoliaHexanoic acidAcid resistanceGlutathione-S-transferaseEsterase activityToxin