2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
2013
Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium
Giordano C, Thorn SL, Renaud JM, Al-Atassi T, Boodhwani M, Klein R, Kuraitis D, Dwivedi G, Zhang P, DaSilva JN, Ascah KJ, deKemp RA, Suuronen EJ, Beanlands RS, Ruel M. Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium. Circulation Cardiovascular Imaging 2013, 6: 982-991. PMID: 24089461, DOI: 10.1161/circimaging.113.000185.Peer-Reviewed Original ResearchConceptsMyocardial blood flowHibernating myocardiumAngiogenic cellsBlood flowSwine modelAdvanced coronary artery diseaseLeft circumflex artery territoryRelevant swine modelCoronary artery diseaseCircumflex artery territoryLeft circumflex arteryCirculating Angiogenic CellsWall motion abnormalitiesMyocardial flow reserveArtery territoryUnderwent placementArtery diseaseEjection fractionCircumflex arteryCell-based therapiesRevascularization approachTomography perfusionMyocardial hibernationAmeroid constrictorPreclinical swine model