2021
Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death
Decuypere JP, Van Giel D, Janssens P, Dong K, Somlo S, Cai Y, Mekahli D, Vennekens R. Interdependent Regulation of Polycystin Expression Influences Starvation-Induced Autophagy and Cell Death. International Journal Of Molecular Sciences 2021, 22: 13511. PMID: 34948309, PMCID: PMC8706473, DOI: 10.3390/ijms222413511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagyCell DeathCell LineEpithelial CellsHumansKidney Tubules, ProximalMicePolycystic Kidney, Autosomal DominantStarvationTRPP Cation ChannelsConceptsProximal tubular epithelial cellsAutosomal dominant polycystic kidney diseaseEarly-stage ADPKD patientsCell deathPC2 expressionDominant polycystic kidney diseaseTubular epithelial cellsRenal cell survivalPolycystin-1Polycystic kidney diseaseCell survivalPolycystin-2Basal autophagyAutophagic cell survivalCell death resistanceADPKD progressionKidney diseaseADPKD patientsLess cell deathPC1 levelsChronic starvationHealthy individualsDuct cellsEpithelial cellsDeathRestoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease
Du Z, Tian X, Ma M, Somlo S, Weinstein AM, Wang T. Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease. JCI Insight 2021, 6: e146041. PMID: 33886508, PMCID: PMC8262298, DOI: 10.1172/jci.insight.146041.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzazepinesDisease Models, AnimalFemaleKidneyKidney Tubules, ProximalMaleMiceMice, KnockoutPolycystic Kidney DiseasesReceptors, Dopamine D1TRPP Cation ChannelsConceptsGlomerular filtration rateGlomerulotubular balanceRenal cyst formationCyst formationReceptor 1 antagonistPolycystic kidney diseaseKidney weightUntreated miceDA1 antagonistControl miceKidney diseaseFiltration rateFractional reabsorptionCystic indexMouse modelCyst growthConditional KOHCO3- absorptionHeterozygous miceSame antagonistsMicePT transportAntagonistEpithelial ciliaHCO3- transport
2012
Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels
Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F. Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels. Cell Reports 2012, 1: 241-250. PMID: 22832196, PMCID: PMC3437542, DOI: 10.1016/j.celrep.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAcidosisActin CytoskeletonAnimalsApoptosisChlorocebus aethiopsCOS CellsCytoprotectionDocosahexaenoic AcidsGene Knockout TechniquesIon Channel GatingKidney Tubules, ProximalMechanotransduction, CellularMiceMice, KnockoutMutant ProteinsPotassium Channels, Tandem Pore DomainProtein SubunitsStress, MechanicalTRPP Cation ChannelsConceptsEpithelial cellsRenal epithelial cellsProximal convoluted tubule epithelial cellsAutosomal dominant polycystic kidney diseaseDominant polycystic kidney diseaseKidney disease statesTubule epithelial cellsPolycystic kidney diseaseHeart failureKidney diseaseImportant pathologiesDisease statesApoptotic cell deathTREK-2K2P channelsCell deathApoptosisCellsAtherosclerosisDiseasePathology