An infection-induced oxidation site regulates legumain processing and tumor growth
Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. An infection-induced oxidation site regulates legumain processing and tumor growth. Nature Chemical Biology 2022, 18: 698-705. PMID: 35332331, PMCID: PMC9246868, DOI: 10.1038/s41589-022-00992-x.Peer-Reviewed Original ResearchMeSH KeywordsCell Transformation, NeoplasticCysteineCysteine EndopeptidasesHelicobacter InfectionsHelicobacter pyloriHumansOxidation-ReductionStomach NeoplasmsConceptsCysteine reactivityOxidation sitesTumor growthChemical proteomicsH. pylori-infected cellsRedox-sensitive cysteinesInduces oxidationReactivityOxidationOxidation EventHuman gastric cellsCarcinogenic infectionsBacterium Helicobacter pyloriXenograft modelHelicobacter pyloriSite-specific lossGastric cellsMost cancersOxidative stressReactive oxygen speciesTumor formationOxygen speciesInfectionTumorigenesisCysteine