2023
Activity‐based Tools for Interrogating Host Biology During Infection
Ramanathan R, Hatzios S. Activity‐based Tools for Interrogating Host Biology During Infection. Israel Journal Of Chemistry 2023, 63 PMID: 37744997, PMCID: PMC10512441, DOI: 10.1002/ijch.202200095.Peer-Reviewed Original ResearchActivity-based protein profilingPost-translational modificationsHost post-translational modificationsHost-microbe interactionsHost biologyCells senseCell signalingMicrobial mechanismsEnzyme functionProtein profilingProtein structureSide-chain reactivityChemical probesInfected cellsHost-directed therapiesPotential targetRapid modulationHost responseSignalingBiologyInfectionEnzymeProfilingPathwayPathogens
2017
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell BR, Angeli J, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell 2017, 171: 273-285. PMID: 28985560, PMCID: PMC5685180, DOI: 10.1016/j.cell.2017.09.021.Peer-Reviewed Original ResearchConceptsRegulated cell deathCell deathPathological cell deathBiosynthesis of glutathioneNumerous biological processesTumor suppressor functionIron-dependent accumulationAreas of biologyRedox biologyFatty acid metabolismBiological processesCellular membranesAmino acidsHeat stressCoenzyme QFerroptosisAcid metabolismBiologyLethal levelsFatty acidsKidney degenerationCancer therapyDegenerative diseasesMetabolismMammals