2022
Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety.
Honig S, Gittelman M, Kaminetsky J, Wang C, Amory J, Rohowsky N, Dudley R, Woun Seo B, Newmark J, Swerdloff R. Two-Year Analysis of a New Oral Testosterone Undecanoate (TU) Formulation in Hypogonadal Men: Efficacy, Impact on Psychosexual Function, and Safety. The Journal Of Sexual Medicine 2022, 19: 1750-1758. PMID: 37057401, DOI: 10.1016/j.jsxm.2022.09.002.Peer-Reviewed Original ResearchConceptsTestosterone replacement therapyPsychosexual Daily QuestionnaireLiver function testsOral TUSerum T concentrationsSexual functionT concentrationsTU therapyHypogonadal menFunction testsEffective long-term treatment optionProstate-specific antigen levelHigh-density lipoprotein cholesterolLong-term treatment optionAdult hypogonadal menOral testosterone undecanoateTotal testosterone levelsSystolic blood pressureTotal T concentrationsActive-controlled trialYears of treatmentLong-term safetySignificant changesEugonadal rangeCardiovascular endpoints
2019
Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses
Gross MS, Reinstatler L, Henry GD, Honig SC, Stahl PJ, Burnett AL, Maria PP, Bennett NE, Kava BR, Kohler TS, Beilan JA, Carrion RE, Munarriz RM. Multicenter Investigation of Fungal Infections of Inflatable Penile Prostheses. The Journal Of Sexual Medicine 2019, 16: 1100-1105. PMID: 31255212, DOI: 10.1016/j.jsxm.2019.05.003.Peer-Reviewed Original ResearchConceptsInflatable penile prosthesisPenile prosthesisFungal infectionsIPP infectionAntifungal prophylaxisIPP implantationDiabetic patientsMulticenter investigationCurrent American Urological Association guidelinesMean body mass indexAmerican Urological Association guidelinesRetrospective institutional review boardExtensive record reviewMulti-institution databaseRecent antibiotic exposurePiperacillin/tazobactamBody mass indexAmpicillin/sulbactamPercent of implantsSecond-generation cephalosporinsPenile prosthesis infectionInstitutional review boardIntravenous antibioticsMean hemoglobinOverweight patients
2016
Trends in Testosterone Replacement Therapy Use from 2003 to 2013 among Reproductive-Age Men in the United States
Rao PK, Boulet SL, Mehta A, Hotaling J, Eisenberg ML, Honig SC, Warner L, Kissin DM, Nangia AK, Ross LS. Trends in Testosterone Replacement Therapy Use from 2003 to 2013 among Reproductive-Age Men in the United States. Journal Of Urology 2016, 197: 1121-1126. PMID: 27789218, PMCID: PMC11056957, DOI: 10.1016/j.juro.2016.10.063.Peer-Reviewed Original ResearchConceptsTherapy useReproductive-age menTherapy usersMen 18Older menTestosterone replacement therapyTruven Health MarketScanLong-term sequelaeCommercial claims databaseYounger age groupsCochran-Armitage testCross-sectional analysisFourfold increaseMen 56Topical gel formulationTestosterone useClaims databaseReplacement therapySignificant threefold increaseInjection usePractice patternsGel usePoisson regressionAge groupsSemen analysis
2015
Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD)
Carson CC, Sadeghi-Nejad H, Tursi JP, Smith TM, Kaufman GJ, Gilbert K, Honig SC. Analysis of the clinical safety of intralesional injection of collagenase Clostridium histolyticum (CCH) for adults with Peyronie's disease (PD). BJU International 2015, 116: 815-822. PMID: 25818264, DOI: 10.1111/bju.13120.Peer-Reviewed Original ResearchConceptsTreatment-related adverse eventsCollagenase clostridium histolyticumPooled safety analysisAdverse eventsSerious AEsPeyronie's diseasePenile haematomaIntralesional injectionClinical studiesSerious treatment-related adverse eventsTreatment-emergent adverse eventsTreatment-related serious AEsOpen-label safetyPlacebo-controlled studySerious adverse eventsSystemic hypersensitivity reactionClostridium histolyticumCorporal ruptureHypersensitivity eventsPenile painMost patientsPenile swellingAntibody levelsCCH treatmentHypersensitivity reactionsMuscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
Li N, Hauser R, Holford T, Zhu Y, Zhang Y, Bassig BA, Honig S, Chen C, Boyle P, Dai M, Schwartz SM, Morey P, Sayward H, Hu Z, Shen H, Gomery P, Zheng T. Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts. British Journal Of Cancer 2015, 112: 1247-1250. PMID: 25826226, PMCID: PMC4385953, DOI: 10.1038/bjc.2015.26.Peer-Reviewed Original Research
2008
The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men
El-Domyati MM, Al-Din AB, Barakat MT, El-Fakahany HM, Honig S, Xu J, Sakkas D. The expression and distribution of deoxyribonucleic acid repair and apoptosis markers in testicular germ cells of infertile varicocele patients resembles that of old fertile men. Fertility And Sterility 2008, 93: 795-801. PMID: 19062002, DOI: 10.1016/j.fertnstert.2008.10.031.Peer-Reviewed Original ResearchConceptsInfertile varicocele patientsDNA repair markersVaricocele patientsFertile menTesticular germ cellsApoptosis markersRetrospective case-control studyRepair markersHuman testicular germ cellsCase-control studyCell proliferation markersApoptosis marker proteinsGerm cellsTesticular specimensImmunohistochemical stainingMAIN OUTCOMEFertile volunteersInfertile menPatientsProliferation markersAbove markersDeoxyribonucleic acid repairTesticular tissueYoung menMen
2006
Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients
Kliman HJ, Honig S, Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test® (EFT®) and good reproductive outcome in donor ovum recipients. Journal Of Assisted Reproduction And Genetics 2006, 23: 299-303. PMID: 16983518, DOI: 10.1007/s10815-006-9061-1.Peer-Reviewed Original ResearchConceptsFunction testsCourse of estrogensOvum donation cyclesUnexplained infertility patientsBetter reproductive outcomesCyclin EOvum recipientsClinical pregnancyEndometrial biopsyInfertility patientsProgesterone supplementationSuch patientsEndometrial receptivityDonation cyclesSuccessful pregnancyPregnancy failureDonor oocytesLeuprolide acetateSole patientUterine preparationsImmunohistochemical stainingReproductive outcomesStimulation protocolTransfer cyclesSuccessful implantationSingle-Blind, Multicenter, Placebo Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon α-2b for Minimally Invasive Treatment for Peyronie’s Disease
Hellstrom WJ, Kendirci M, Matern R, Cockerham Y, Myers L, Sikka SC, Venable D, Honig S, McCullough A, Hakim LS, Nehra A, Templeton LE, Pryor JL. Single-Blind, Multicenter, Placebo Controlled, Parallel Study to Assess the Safety and Efficacy of Intralesional Interferon α-2b for Minimally Invasive Treatment for Peyronie’s Disease. Journal Of Urology 2006, 176: 394-398. PMID: 16753449, DOI: 10.1016/s0022-5347(06)00517-9.Peer-Reviewed Original ResearchConceptsIntralesional interferon alpha-2bAlpha-2bInterferon alpha-2bPeyronie's diseasePenile curvatureInterferon alpha-2b therapyPlaque sizeAlpha-2b therapyIntralesional interferon αMean International IndexErectile Function scoreFlu-like symptomsBlood flow improvementParallel studyPenile painPlacebo-ControlledPain resolutionConsecutive patientsErectile functionFunction scoresMean ageControl armInternational IndexInvasive treatmentStudy completion
2005
Herniorrhaphy With Polypropylene Mesh Causing Inguinal Vasal Obstruction
Shin D, Lipshultz LI, Goldstein M, Barmé GA, Fuchs EF, Nagler HM, McCallum SW, Niederberger CS, Schoor RA, Brugh VM, Honig SC. Herniorrhaphy With Polypropylene Mesh Causing Inguinal Vasal Obstruction. Annals Of Surgery 2005, 241: 553-558. PMID: 15798455, PMCID: PMC1357057, DOI: 10.1097/01.sla.0000157318.13975.2a.Peer-Reviewed Original ResearchConceptsInguinal hernia repairPolypropylene meshVasal obstructionHernia repairMesh herniorrhaphyContralateral testicular atrophyFibroblastic responseInguinal hernia operationsCases of azoospermiaYoung reproductive ageSolitary testicleBilateral obstructionUrologic evaluationPatient agePatient characteristicsOperative findingsSurgical explorationUnilateral obstructionMultiinstitutional experienceTesticular atrophyEpididymal obstructionFuture fertilityReproductive ageSurgical reconstructionLong-term effects
2004
LAPAROSCOPIC MOBILIZATION OF THE RETROPERITONEAL VAS DEFERENS FOR MICROSCOPIC INGUINAL VASOVASOSTOMY
KIM A, SHIN D, MARTIN TV, HONIG SC. LAPAROSCOPIC MOBILIZATION OF THE RETROPERITONEAL VAS DEFERENS FOR MICROSCOPIC INGUINAL VASOVASOSTOMY. Journal Of Urology 2004, 172: 1948-1949. PMID: 15540762, DOI: 10.1097/01.ju.0000140449.39217.b0.Peer-Reviewed Original Research
1997
The prevalence of cystic abnormalities of the prostate involving the ejaculatory ducts as detected by transrectal ultrasound
Kim E, Onel E, Honig S, Lipshultz L. The prevalence of cystic abnormalities of the prostate involving the ejaculatory ducts as detected by transrectal ultrasound. International Urology And Nephrology 1997, 29: 647-652. PMID: 9477362, DOI: 10.1007/bf02552181.Peer-Reviewed Original ResearchConceptsCystic lesionsTransrectal ultrasoundInfertile menEjaculatory ductPopulation of menScreening groupDuctal obstructionMethodsThe prevalencePrevalence increasesProstate cancerCystic abnormalitiesLarge seriesLesionsProstateSemen analysisPrevalenceFertile malesDuctMenAbnormalitiesRiskUltrasoundPopulationPurposeToInfertility
1994
Significant medical pathology uncovered by a comprehensive male infertility evaluation**Presented at the conjoint meeting of The American Fertility Society and the Canadian Fertility and Andrology Society, Montreal, Quebec, Canada, October 11 to 14, 1993.
Honig S, Lipshultz L, Jarow J. Significant medical pathology uncovered by a comprehensive male infertility evaluation**Presented at the conjoint meeting of The American Fertility Society and the Canadian Fertility and Andrology Society, Montreal, Quebec, Canada, October 11 to 14, 1993. Fertility And Sterility 1994, 62: 1028-1034. PMID: 7926114, DOI: 10.1016/s0015-0282(16)57069-1.Peer-Reviewed Original ResearchConceptsSignificant medical pathologyMale infertility clinicPhysical examinationSemen analysisInfertility clinicHormone profilesMedical pathologyMesonephric duct anomaliesBladder neck closureMale infertility evaluationMale factor infertilityAmerican Fertility SocietyComplete physical examinationSeries of therapiesMean sperm concentrationMean sperm motilityUnexplained infertilityUrologic evaluationDuct anomaliesInfertility evaluationInitial presentationEndocrine abnormalitiesFactor infertilityNeck closureCanadian Fertility
1993
Non-Hodgkin's lymphoma can mimic renal adenocarcinoma with inferior vena caval involvement
Wagner J, Honig S, Siroky M. Non-Hodgkin's lymphoma can mimic renal adenocarcinoma with inferior vena caval involvement. Urology 1993, 42: 720-723. PMID: 8018141, DOI: 10.1016/0090-4295(93)90543-j.Peer-Reviewed Original ResearchConceptsInferior vena cavaTumor thrombusRenal veinVena cavaRenal lymphomaRenal adenocarcinomaInferior vena caval involvementMalignant urologic conditionsVena caval involvementNon-Hodgkin lymphomaCases of lymphomaCaval involvementVascular involvementHodgkin's lymphomaGenitourinary involvementDifferential diagnosisUrologic conditionsLymphomaCavaThrombusUreteral encasementAdenocarcinomaVeinPrevious reportsInvolvement
1992
Microscopic epididymal sperm aspiration (MESA): A new option for treatment of the obstructive azoospermia associated with cystic fibrosis
Oates R, Honig S, Berger M, Harris D. Microscopic epididymal sperm aspiration (MESA): A new option for treatment of the obstructive azoospermia associated with cystic fibrosis. Journal Of Assisted Reproduction And Genetics 1992, 9: 36-40. PMID: 1617248, DOI: 10.1007/bf01204112.Peer-Reviewed Original ResearchConceptsMicroscopic epididymal sperm aspirationEpididymal sperm aspirationSperm aspirationCystic fibrosisCongenital absenceObstructive azoospermiaVas deferensTransvaginal oocyte retrievalCystic fibrosis populationAvenues of treatmentLife-threatening diseasePartial zona dissectionInseminations of spermOocyte retrievalMale patientsTreatment optionsClinical usefulnessQuality of spermFertility potentialZona dissectionGenetic testingIndian malesFibrosisInvariable absenceReproductive technologies